糖原合成酶激酶-3在炎症反应中的研究  

The research of glycogen synthase kinase-3 in the inflammatory response

作　　者：张丹丹[1] 李璐[1] 陈煜[1] 

机构地区：[1]首都医科大学附属北京佑安医院人工肝中心,北京100069

出　　处：《胃肠病学和肝病学杂志》2013年第11期1172-1174,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：十二五重大专项课题资助项目(NO.2012ZX10004904-003-001;NO.2012ZX10002004-006;NO.2013ZX10002002-006-001)

摘　　要：糖原合成酶激酶-3(GSK3)是一种丝/苏氨酸磷酸激酶,在原发性和继发性免疫系统均发挥重要作用,其增加促进炎症因子(IL-1β、IL-2、IL-6等)的产生,抑制GSK3活性后可减轻炎症反应同时保护机体免受免疫介导的病理损伤。GSK3活化与阿尔茨海默病、糖尿病、急性肾衰竭等疾病发生、发展有一定的相关性。本文就GSK3在不同免疫系统及其参与相关疾病的研究进展作一综述。Glycogen synthase kinase-3 （GSK3） is a serine/threonine kinase,which plays an important role in primary and secondary immune system and increases production of inflammatory cytokines （IL-1β,IL-2,IL-6,et al）.Inhibition of GSK3 activity can reduce inflammation and protect the body from immune-mediated pathological damage.GSK3 activation and the development of Alzheimer＇ s disease,diabetes,acute renal failure and other diseases have a certain relevance.In this review,we will discuss the function of GSK3 in different immune systems and its related diseases.

关 键 词：糖原合酶激酶3(GSK3) 免疫反应 炎症因子 

分 类 号：R575[医药卫生—消化系统]