载脂蛋白B/A1比值与IMT在预测心脑血管病风险相关性的性别差异  

Gender Differences In Dependablity Between Anticipation for Risk of Cardia-Cerebrovascular Disease with the apo B/apo A1 Ratio and Carotidartery Intimal-Medial Thickness

作　　者：叶桂云[1] 胡望平[2] 池细俤[1] 张忠源[1] 陈碧华[1] 陈子国[1] 张永平[1] 徐尚华[1] 魏僖僖 

机构地区：[1]福建医科大学附属南平第一医院,353000 [2]南京军区福州总医院,350025

出　　处：《医学研究杂志》2013年第11期149-152,共4页Journal of Medical Research

摘　　要：目的探讨载脂蛋白B/A1比值(apoB/apoA1)与颈动脉内膜中层厚度(intimal-media thickness,IMT)在预测动脉粥样硬化风险的价值及不同性别间风险性的差异。方法分析测量400例受试者血脂水平,计算apoB/apoA1,检测IMT。结果不同性别两组年龄,男性平均年龄66.8±11.97岁,女性平均年龄65.15±11.03岁,两组比较无统计学差异(P>0.05)。不同性别分组各项指标的比较中,女性组TG、TC、HDL、LDL、apoA1、apoB明显高于男性组(P<0.01);患者组各指标与IMT的相关性分析,apoB/apoA1与IMT相关性最强(P<0.001);不同性别患者组各指标与IMT相关性分析,女性患者组apoB/apoA1相关性最强(P<0.001)。将患者IMT分成3组的比较中,apoB/apoA1差异明显(P<0.01)。结论 apoB/apoA1与IMT密切相关,尤其对老年女性。ApoB/apoA1是心脑血管病动脉粥样硬化重要的预测指标及最危险因素。Objective To investigate the value of the apoB/apoA1 ratio and carotidartery intimal - medial thickness（IMT） in carot- id atherosclerosis risking and study gender difference of carotid atherosclerosis risking for the apoB/apoaA1 ratio and IMT. Methods The lipid levels and IMT in 400 patients were determined and the apoB/apoA1 were calculated. Results The mean age of male （66.8 ＋ 11.97 years） were not predominance difference than that of female （65.15 ＋ 11.03 years） （P 〉 0.05 ）. Through gender classified into two groups, the levels of CHOL, TG, HDL, LDL, apoA1 and apoB in women group were obviously higher than that of male group（P 〈 0. 01 ）. The apoB/apoA1 ratio was strongest correlation with IMT in patients lipid indexes and IMT correlation analysis （ P 〈 0. 001 ）. The apoB/apoA1 ratio was strongest correlation for women group than other groups in lipid Indexes and IMT correlation analysis of different gender patients（P 〈 0. 001 ）. The patients were divided into three groups with CAS diagnosis standard of IMT, the apoB/apoA1 ratio was significant different （P 〈0.01 ）. Conclusion The apoB/apoA1 ratio is closely related to IMT, especially for older women. The apoB/ apoA1 ratio is an important predictor of cardio - cerebrovascular disease of atherosclerosis and a superlative risk factor.

关 键 词：载脂蛋白B A1比值 颈动脉内膜中层厚度 动脉粥样硬化 风险预测 性别差异 

分 类 号：R749.3[医药卫生—神经病学与精神病学]