原发性胆汁性肝硬化合并干燥综合征的临床特点分析  

Clinical characteristics of primary biliary cirrhosis complicating Sj（o）gren syndrome

作　　者：高丽霞[1] 王立[1] 张奉春[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院免疫风湿科,100032

出　　处：《中华医学杂志》2013年第43期3457-3459,共3页National Medical Journal of China

基　　金：国家十一五科技支撑计划（2008BAI59B03）

摘　　要：目的 分析原发性胆汁性肝硬化（PBC）合并干燥综合征（SS）的特点,寻找诊断依据.方法分析北京协和医院2006至2009年93例PBC合并SS、64例单纯的PBC和57例单纯SS患者的临床、实验室以及病理学资料结果 PBC合并SS组年龄（53±10）岁比单纯PBC（50±11）岁（P＜0.05）和SS组（48±14）岁（P＜0.05）的年龄均偏大;SS患者发热较PBC合并SS患者更多见（P＜0.05）;PBC合并SS比较单纯的PBC抗SSA抗体（P＜0.05）和抗着丝点抗体（ACA）（P＜0.05）阳性率明显增加;PBC合并SS比较单纯的SS,抗SSA（P＜0.05）和抗SSB抗体（P＜0.05）单纯的SS患者更多见.结论 PBC合并SS是一种特殊的亚群,它同时具有PBC和SS的特点,又与之不完全相同,抗SSA抗体和ACA抗体的出现有助于PBC合并SS的诊断.Objective To explore the clinical characteristics of primary biliary cirrhosis （PBC） with Sjogren syndrome （SS） so as to seek diagnostic rationales. Methods Sixty-four PBC patients, 57 SS patients and 93 PBC with SS patients were recruited from Peking Union College Hospital between 2006 and 2009. And their clinical, laboratory and pathological data were analyzed. Results The patients of PBC with SS （53 ± 10） years were older than those of PBC （ 50 ± 11 ） years （ P 〈 0. 05 ） or SS （48 ± 14） years （ P 〈 0.05 ） ; Comparing PBC with SS and SS, fever was more in SS （P 〈 0. 05 ） ;compare with PBC, the positive rates of anti-centromere antibody （ACA） （ P 〈 0. 05 ） and anti-SSA antibody （ P 〈 0. 05 ） increased obviously in PBC with SS. Comparing with SS, the positive rate of anti-SSA antibody （P 〈 0. 05 ） and anti-SSB antibody （P 〈 0. 05 ）were apparently increased obviously in PBC with SS. Conclusion PBC with SS is a special subgroup with the characteristic both PBC and SS. But it can not differentiate from PBC or SS, Anti-SSA antibody and ACA are helpful for diagnosis of PBC with SS.

关 键 词：原发性胆汁性肝硬化 干燥综合征 抗SSA抗体 抗着丝点抗体 

分 类 号：R575.2[医药卫生—消化系统]