帕金森病患者伴发抑郁对认知障碍和运动障碍的影响  

Effect of Depression on Cognitive Dysfunction and Movement Dysfunction in Patients with Parkinson's Disease

作　　者：韩英[1] 刘楠[2] 黄慧玲[1] 徐春平[1] 晏泽辉[1] 

机构地区：[1]福建医科大学附属协和医院干部病房,福州350001 [2]福建医科大学附属协和医院神经内科,福州350001

出　　处：《福建医科大学学报》2013年第4期232-235,共4页Journal of Fujian Medical University

摘　　要：目的探讨帕金森病(PD)患者伴发抑郁与认知功能障碍及运动障碍之间的影响。方法采用汉密尔顿抑郁量表(HAMD)对46例PD患者进行评分,HAMD≥17分为抑郁组,HAMD<17分为非抑郁组;应用简易精神状态检查(MMSE)、画钟测验(CDT)、词语流畅性测验(VFT)、统一PD评价量表(UPDRS)运动分量表评定两组患者的认知功能和运动功能,计算震颤症状得分与运动迟缓症状得分之比,>0.5者为震颤型组,≤0.5者为强直-少动型组,分析两组的HAMD评分情况,HAMD评分与比值之间的Pearson相关系数。结果抑郁组和非抑郁组之间认知功能评分(MMSE、CDT、VFT评分)和运动功能评分(运动迟缓评分)差别具有统计学意义(分别为P<0.01,P<0.05,P<0.01,P<0.01),而震颤评分无统计学意义(P>0.05);强直少动型组HAMD评分明显高于震颤型组(P<0.01),同时HAMD评分与震颤评分/运动迟缓评分之比之间存在负相关(r=-0.523,P<0.01)。结论 PD患者抑郁情绪会加重认知功能障碍及运动功能障碍程度。Objective To investigate effect of depression on cognitive and movement dysfunction in patients with Parkinson＇s disease （PD）. Methods 46 patients with PD patients were enrolled and eval- uated by Hamilton depression rating Scale （HAMD）. Patients with scores〈17 were defined as depres- sion, and scores 17 as non-depression. Cognitive function and motor function were assessed by Mini- mental state examination （MMSE）,Clock drawing test （CDT）, Verbal fluency test （VFT） and Unified parkinsons disease rating scale（UPDRS） subscales. The ratio of the tremor symptoms seore/bradykine- sia symptoms score was calculated, patients with scores 〈0. 5 were defined as tremor type group, and those with scores 40.5 as tonic-less acting group. The correlation of HAMD score and the ratio of the tremor symptoms score/bradykinesia symptoms score were analyzed by the Pearson correlation between depression and non-depression groups. Results In PD patients with or without depression, there was statistically significant differences in cognitive function score （MMSE, CDT, VFT score） and motor func- tion score （bradykinesia score） P〈0.05 or P〈0.01 respectively however, there was no significant differ- ence in tremor score. The HAMD score in Tonic less-action group was significantly higher than that in the tremor-type group P〈0.01）. There was a negative correlation between the HAMD score and the ratio of tremor score / bradykinesia score（r=--0. 523,P〈0.01）. Conclusions PD patients with depres- sion have worse cognitive dysfunction and movement dysfunction.

关 键 词：帕金森病 抑郁 认知障碍 运动障碍 精神病状态评定量表 

分 类 号：R742.5[医药卫生—神经病学与精神病学]