LEEP治疗宫颈上皮内瘤变临床疗效及其预后影响因素  

The Clinical Effects of and the Prognostic Factors for the Patients with CIN Treated with LEEP

作　　者：石新荷[1] 何绍民 

机构地区：[1]浙江省绍兴市人民医院妇科,312000 [2]浙江省绍兴市第二人民医院妇科

出　　处：《中华全科医学》2013年第12期1896-1898,共3页Chinese Journal of General Practice

摘　　要：目的探讨LEEP对宫颈上皮内瘤变(CIN)的治疗效果及患者预后的影响因素。方法 LEEP治疗267例CIN患者,分析临床效果,并根据治疗结局将患者分为治愈组与复发组,使用SPSS 13.0统计软件进行统计学分析,研究影响其预后的相关因素。结果 267例CIN患者均顺利完成手术,随访2年治愈率为92.1%(246/267),复发率为7.9%(21/267);治愈组与复发组患者在年龄、是否吸烟、术前HPV感染、术前病理结果、手术切缘状态、病变是否累及腺体以及病变范围等方面比较差异具有统计学意义(P<0.01),而在初次性生活年龄方面比较差异无统计学意义(P>0.05)。结论 LEEP对于CIN的治疗,具有创伤小、用时少、术后恢复快、治愈率高等特点,患者年龄、吸烟、术前HPV感染、术前病理结果、手术切缘状态、病变是否累及腺体以及病变范围为影响预后的相关因素,应给予足够重视,制定可行的手术方案,以期彻底治愈。Objective To explore the clinical effects and the prognostic factors for the patients with CIN treated with LEEP. Methods 267 patients with CIN were treated with LEEP, the clinical effects were analyzed, they were divided into the cured group and recurrent group according to the treatment outcome, and then the prognostic factors were analyzed. Results 267 patients with CIN were successfully operated, the cure rate was 92.1% （246/267） followed up for 2 years, and the recurrence rate was 7.9% （21/267） ;there were significantly different in age, smoking or not, preoperative HPV infection, preoperative pathological results, surgical margin status, lesion involving glands or not, and extent of disease（ P 〈 0.01 ） ;but no significant difference in age of first sexual（P 〉 0.05 ）. Conclusion LEEP had less trauma, with less time, rapid postoperative recovery, and high cure rate in patients with CIN, patients＇ age, smoking, preoperative HPV infection, preoperative pathological results, surgical margin status, whether the lesion involving glands, and extent of disease were related prognostic factors, we should pay attention to these factors, and develop a viable surgical solution to cure it completely.

关 键 词：LEEP 宫颈上皮内瘤变 疗效 预后影响因素 

分 类 号：R737.33[医药卫生—肿瘤] R730.56[医药卫生—临床医学]