Sperm Mitochondria in Reproduction:Good or Bad and Where Do They Go?  

作　　者：Shi-Ming Luo Heide Schatten Qing-Yuan Sun 

机构地区：[1]Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong,Qingdao Agricultural University [2]Department of Veterinary Pathobiology,University of Missouri,Columbia [3]State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences

出　　处：《Journal of Genetics and Genomics》2013年第11期549-556,共8页遗传学报（英文版）

基　　金：supported by the Major Basic Research Program(Nos.2012CB944404 and 2011CB944501);the National Natural Science Foundation of China(No.30930065)to Q.Y.S

摘　　要：The mitochondrion is the major energy provider to power sperm motility. In mammals, aside from the nuclear genome, mitochondrial DNA （mtDNA） also contributes to oxidative phosphorylation to impact production of ATP by coding 13 polypeptides. However, the role of sperm mitochondria in fertilization and its final fate after fertilization are still controversial. The viewpoints that sperm bearing more mtDNA will have a better fertilizing capability and that sperm mtDNA is actively eliminated during early embryogenesis are widely accepted. However, this may be not true for several mammalian species, including mice and humans. Here, we review the sperm mitochondria and their mtDNA in sperm functions, and the mechanisms of maternal mitochondrial inheritance in mammals.The mitochondrion is the major energy provider to power sperm motility. In mammals, aside from the nuclear genome, mitochondrial DNA （mtDNA） also contributes to oxidative phosphorylation to impact production of ATP by coding 13 polypeptides. However, the role of sperm mitochondria in fertilization and its final fate after fertilization are still controversial. The viewpoints that sperm bearing more mtDNA will have a better fertilizing capability and that sperm mtDNA is actively eliminated during early embryogenesis are widely accepted. However, this may be not true for several mammalian species, including mice and humans. Here, we review the sperm mitochondria and their mtDNA in sperm functions, and the mechanisms of maternal mitochondrial inheritance in mammals.

关 键 词：Mitochondrial DNA Maternal inheritance Paternal inheritance Autophagy Oxidative phosphorylation UBIQUITINATION 

分 类 号：Q954.4[生物学—动物学]