间变性大细胞淋巴瘤30例患者外周血内皮祖细胞预后价值分析  

Prognostic value analysis of detection of endothelial progenitor cell in 30 patients with anaplastic large cell lymphoma

作　　者：申政磊[1] 尹列芬[2] 毛文文 梁进[1] 沈丽达[1] 王存德[1] 杨玲[2] 

机构地区：[1]云南省肿瘤医院化疗中心,昆明650118 [2]昆明医学院第二附属医院血液科 [3]昆明市第二人民医院老年科

出　　处：《白血病．淋巴瘤》2013年第11期655-657,共3页Journal of Leukemia & Lymphoma

基　　金：云南省教育厅基金（0920031）;国家自然科学基金（81241122）;国家自然科学基金（8136008）

摘　　要：目的 探讨间变性大细胞淋巴瘤（ALCL）患者外周血中内皮祖细胞（EPC）的数量变化在疾病预后中的意义.方法 采用流式细胞术检测30例ALCL患者以及对照健康体检者10名外周血中EPC的数量,进行绝对计数,并与临床预后指标国际预后指数（IPI）评分以及间变淋巴瘤细胞激酶（ALK）资料进行对比.结果 ALCL患者治疗前外周血EPC绝对计数为（15.530±28.659）个/μl,与对照组的（0.515±0.294）个/μl相比较,差异有统计学意义（P＜ 0.001）.根据IPI评分标准,把ALCL患者分为低危组（0～1分）、中危组（2～3分）、高危组（4～5分）三组,外周血EPC绝对计数分别为（6.508±7.356）个/μl、（16.830±24.273）个/μl、（21.521±36.057）个/μl,在低危组与中危组、高危组中差异有统计学意义（P＜ 0.01）;中危组与高危组中差异无统计学意义（P＞0.05）;外周血EPC绝对计数在ALK＋与ALK-ALCL患者中分别为（8.367±9.609）个/μl和（22.541±20.845）个/μl,差异有统计学意义（P＜0.01）.ALCL患者外周血EPC绝对计数分为＜20个/μl组与≥20个/μl组,两组间在60周内生存曲线差异有统计学意义.结论 外周血EPC绝对计数与ALCL临床病情进展程度可能有一定的关系,有可能成为评价患者治疗效果及预后的指标之一.Objective To check the changes of endothelial progenitor cell （EPC） number of patients with anaplastic large cell lymphoma （ALCL） in the peripheral blood,investigate their clinical significance.Methods The number of EPC in blood was determined by FCM method in 30 patients with ALCL and 10 healthy cases as the control group.Results The number of EPC in the peripheral blood of patients with ALCL before treatment was significantly higher （15.530±28.659/μl） than that in control group （0.515 ±0.294/μl,P 〈 0.001）.The number of EPC of ALCL patients in the high-risk groups （21.521±36.057/μl） and the middle-risk groups （16.830±24.273/μ1） differently increaasd than that of the low-risk group （6.508±7.356/μl,P 〈 0.01）,but between the high-risk groups and the middle-risk groups there was no significant value （P 〉 0.05）.There were significant difference between the number of EPC of ALK＋-ALCL （8.367±9.609/μl） and ALK-ALCL （22.541± 20.845/μl） patients （P 〈 0.01）.The survive curve before 60 weeks had significant difference between groups of 〉20/μl and 〈20/μl of EPC.Conclusion EPC may be correlated with progression of the disease in a certain degree.Dynamic observation with the level of EPC may be used to evaluate the treatment outcomes and act as a prognostic marker for ALCL.

关 键 词：EPC绝对计数 淋巴瘤 大细胞 间变性 流式细胞术 

分 类 号：R733.1[医药卫生—肿瘤]