2008年版世界卫生组织造血与淋巴组织肿瘤分类中与EB病毒相关的淋巴瘤概述  

Overview on EB virus associated lymphomas in 2008 WHO classification of tumours of haematopoietic and lymphoma tissues

作　　者：张甜甜(综述)[1] 付骞千(综述)[1] 翟琼莉(审校)[1] 

机构地区：[1]天津医科大学肿瘤医院病理科中美淋巴血液诊治中心天津市肿瘤防治重点实验室,300060

出　　处：《白血病．淋巴瘤》2013年第11期692-694,共3页Journal of Leukemia & Lymphoma

基　　金：国家自然科学基金（81272361）

摘　　要：EB病毒（EBV）是一种普遍存在的γ-疱疹病毒,全世界90％的成年人存在无症状感染.EBV与经典型霍奇金淋巴瘤、某些类型的B细胞淋巴瘤、T细胞/NK细胞淋巴瘤密切相关.研究表明,EBV潜伏感染的基因表达产物对淋巴瘤的发生起到了启动和（或）促进作用,并为EBV相关淋巴瘤免疫治疗提供了依据.文章主要就2008年版世界卫生组织造血与淋巴组织肿瘤分类中与 EBV相关淋巴瘤的类型作一综述.EB virus （EBV） is a ubiquitous y-herpes virus,which asymptomatically infects greater than 90 % of the world＇s population.EBV is closely related to development of several kinds of lymphomas that include B-,T-and NK-cell derived.Subsequent studies have proven that EBV gene expression product plays an activating and/or promoting role on lymphomagenesis,and paves the way for EBV associated lymphomas immunotherapy.This review focuses on the EBV associated lymphomas in 2008 WHO classification of tumours of haematopoietic and lymphoma tissues.

关 键 词：EB病毒 淋巴瘤 霍奇金 淋巴瘤 B细胞 淋巴瘤 NK T细胞 

分 类 号：R733.1[医药卫生—肿瘤]