葡萄糖耐量因子功能牛奶对糖耐量低减小鼠干预作用的研究  

The study of the intervention effect of GTF functional milk on IGT mice

作　　者：李津[1] 冯前进[1] 宋强[1] 杜道辉[2] 

机构地区：[1]山西中医学院,山西太原030024 [2]湖北省武汉市黄陂区人民医院,湖北武汉430300

出　　处：《中国食品卫生杂志》2013年第6期505-508,共4页Chinese Journal of Food Hygiene

基　　金：科技部国际科技合作项目(2006DFA32490);山西省科技基础条件平台建设项目(2009091010);山西省专利推广实施资助项目(131005)

摘　　要：目的观察葡萄糖耐量因子(GTF)功能牛奶对糖耐量低减(IGT)小鼠的干预作用,为研究开发有效干预IGT的保健牛奶提供依据。方法除空白对照组外,模型对照组、二甲双胍组、富铬酵母组、普通牛奶组和GTF功能牛奶低、中、高剂量组采用D-半乳糖腹腔注射法诱导IGT,造模14 d后,同时灌胃给药42 d,观察空腹血糖、糖负荷后2 h血糖、甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白、空腹胰岛素、胰岛素抵抗指数。结果 GTF功能牛奶低、中、高剂量组糖负荷后2 h血糖、空腹胰岛素、胰岛素抵抗指数与模型对照组相比差异有统计学意义(P<0.01,P<0.05),GTF功能牛奶中、高剂量组甘油三酯、总胆固醇、高密度脂蛋白与模型对照组相比差异有统计学意义(P<0.05,P<0.01),GTF功能牛奶中、高剂量组糖负荷后2 h血糖、甘油三酯、总胆固醇与富铬酵母组相比差异有统计学意义(P<0.05),GTF功能牛奶高剂量组空腹胰岛素、胰岛素抵抗指数与富铬酵母组相比差异有统计学意义(P<0.05)。结论 GTF功能牛奶可降低IGT小鼠的血糖及血脂水平,改善胰岛素抵抗,且经过奶牛的生物转化作用,其生物活性进一步提高。Objective To observe the intervention effect of GTF functional milk on IGT mice and provides the basis for develop milk to intervent IGT effectively. Methods Except for normal control group, IGT mice of model control group, metformin group, chromium-rich yeast group, ordinary milk group, low, medium and high dose of GTF functional milk group were adopted D-galactose by intraperitoneal injection. After 14 days, at the same time the mice were adopted by intragastric administration to observe the fasting blood sugar, 2-hour blood glucose, triglyceride, total cholesterol, high- density lipoprotein cholesterol, low density lipoprotein cholesterol, fasting insulin, insulin resistance index 42 days later. Results 2-Hour blood glucose, fasting insulin, insulin resistance index of low, medium and high dose of GTF functional milk groups compared with the model control group, the difference was statistically significant （P 〈 0. 01, P 〈 0.05 ）. Triglyceride, total cholesterol, high-density lipoprotein cholesterol of medium and high dose of GTF functional milk groups compared with the model control group, the difference was statistically significant （ P 〈 0. 01, P 〈 0.05 ）. 2-Hour blood glucose, triglyceride, total cholesterol, insulin resistance index of medium and high dose of GTF functional milk groups compared with the chromium-rich yeast group, the difference was statistically significant （P 〈 0. 05 ）. Fasting insulin, insulin resistance index of high dose of GTF functional milk group compared with the chromium-rich yeast group, the difference was statistically significant （P 〈0 . 05 ）. Conclusion The GTF functional milk could reduce the levels of blood glucose and blood lipid and improve insulin resistance on IGT mice. After cow＇s biotransformation, its biological activity could be further improved.

关 键 词：葡萄糖耐量因子 铬 牛奶 糖耐量低减 D-半乳糖 保健食品 

分 类 号：R587.1[医药卫生—内分泌]