血清透明质酸在肝硬变诊断中的临床价值  

Serum Hyaluronate in Diagnosis of Cirrhosis

作　　者：罗周荣[1] 王淑楷 曾向军[1] 陈玉丽[1] 张忠英[2] 张志坚[2] 张联娜[2] 

机构地区：[1]福建医学院附属第一医院内一科 [2]福建医学院检验系免疫教研室

出　　处：《福建医学院学报》1991年第2期134-136,共3页

摘　　要：以放射免疫法检测70例病人和46倒正常健康成人的血清透明质酸(HA)。病人分为慢性肝炎组(包括慢迁肝、慢活肝)、肝硬化组、急肝组和非肝病组。除慢迁肝和内科其他病外,各组HA与正常对照组(36.42±13.79μg/L)差异显著(P<0.05)。尤其是慢活肝和肝硬化,其均值分别为411.82±222.56μg/L和477.39±201.9μg/L;肝病均值呈慢迁肝→慢活肝→肝硬化阶梯上升。以血清HA≥250μg/L(风湿病的(?)±s的近似值)作为肝硬变的预测指标,优于常规的肝功检查。In the present study, the serum hyaluronate (HA) in 70 patients and 46 normal adults was measured with sensitive RIA to investigate the change of serum HA concentration in liver deseases. Our study group was divided chronic hepatitis (include CPH & CAH);cirrhosis;acute hepatitis;nonhepatic disease subgroups with normal adult as control group. The serum HA values between four subgroups and control group(36.42±13.79μg/L) differed significantly (P<0.05),excepted CPH and miscellaneous disease,with greater difference in hepatic disease and nonhepatic disease subgroups (P<0.05). HA value of CAH and cirrhosis were separately 411. 82±222.56 and 477.39±201.90μg/L. The level of HA gradually raised with seriousness of liver damage from CPH→CAH→cirrhosis. As a predictive indicator, it is more sensitive than routine liver function parameters making feasible the diagnosis of cirrhosis.

关 键 词：透明质酸 肝硬变 诊断 

分 类 号：R575.204[医药卫生—消化系统]