人眼房水心钠素含量与原发性闭角型青光眼关系的研究  

Research of the relationship between the concentration of atrial natriuretic factor in aqueous humor of human eyes and primary angle closure glaucoma

作　　者：梁平[1] 卞春及[1] 张静馨 李惠萍 

机构地区：[1]南京医科大学第一附属医院眼科,210029

出　　处：《眼科研究》2000年第6期500-502,共3页Chinese Ophthalmic Research

摘　　要：目的　探讨人眼组织中心钠素的含量分布及其与原发性闭角型青光眼 (PACG)之间的关系。方法　应用放免技术测定了 2 2只正常尸眼葡萄膜、玻璃体及 10例老年性白内障病人 ,2 1例原发性闭角型青光眼病人房水中心钠素的含量。结果　正常人眼房水、葡萄膜及玻璃体组织中均有心钠素的存在 ;青光眼组病人房水中心钠素含量明显高于对照组。ObjectiveTo study the concentrations of atrial natriuretic factor(ANF)in human eyes and the relationship between ANF concentration in aqueous humor of human eyes and primary angle closure glaucoma(PACG).MethodsANF concentrations were determined with radio immunoreaction in uvea and vitreous of 22 human eyes and that in aqueous humour of 10 age related cataract patients(control eye)and 21 PACG patients;Glaucomatous eyes were composed of group A(12 cases with normal preoperative intraocular pressure)and group B(9 cases with high preoperative intraocular pressure).ResultsImmunoreactive ANF was detected in human aqueous humour,uvea and vitrous.ANF concentration in iris,ciliary and choroid were (83±28)pg/mg,(53±30)pg/mg and(58±32)pg/mg respectively.The concentration in aqueous humour of control group,group A and group B were(63 6±7 6)pg/ml,(118 6±42 8)pg/ml and(98±29 4)pg/ml respectively.The mean ANF concentration in PACG group was significantly higher than that in control group.ConclusionAbnormal change of ANF concentration in aqueous humour of human eyes may play an important role in pathological mechanism of PACG.

关 键 词：心钠素 闭角型青光眼 房水 PACG 含量 

分 类 号：R775.2[医药卫生—眼科]