宫颈癌预后影响因素的临床分析及研究  

Clinical analysis of prognostic effect of COX-2 and HPV16-E6 on patients with cervical cancer

作　　者：张莉华[1] 辛华栋[1] 李丽[1] 段爱红[1] 赵京梅[1] 

机构地区：[1]邯郸市中心医院,河北邯郸056001

出　　处：《中国热带医学》2013年第10期1272-1274,1292,共4页China Tropical Medicine

摘　　要：目的研究环氧合酶-2(cyclooxygenase-2,COX-2)、人乳头瘤病毒16-E6(human papillomavirus16-E6,HPV16-E6)及临床病理特征对宫颈癌患者预后的影响。方法采用免疫组化S-P法,检测92例接受综合治疗的宫颈癌患者石蜡切片中COX-2、HPV16-E6的表达情况,探讨COX-2及HPV16-E6对宫颈癌预后的影响。结果COX-2、HPV16-E6及病理分级、临床分期、淋巴结转移、病灶直径、宫旁浸润或脉管瘤栓对宫颈癌预后的影响有统计学意义(P<0.05),年龄、病理类型、治疗方式、肌层浸润深度对患者的预后无统计学意义(P>0.05)。结论 COX-2、HPV16-E6、临床分期、淋巴结转移、宫旁浸润或脉管瘤栓为宫颈癌的独立预后因素。Abstract：Objective To investigate the prognostic effect of COX-2.HPV16-E6 on patients with cervical cancer. Methods The clinieopathologie and follow-up data of 92 patients with cervical cancer received integrative therapy from Mar.2004 to Dee.2009 were collected and analyzed. The expression of COX-2 and HPV16-E6 protein of the cervical epithelial cancer was detected with immunohistochemical techniqueand to the prognostic effect of COX-2 and HPV16-E6 on cervical cancer cases was investigated. Results The 3-years overall survival rate was 82.0%. Univariate and multi-factor analysis manifested that pathological grade, clinical stage, pelvic lymph node metastasis, tumor size, fatero-uterus or vessel infiltration,COX-2 and HPV 16-E6 showed significant differemce on the prognosis （P〈0.05）. Age,pathological type,thempic modality,muscular layer invasive depth did not show statistically significant difference （P〉O.05）. Conclusions Cclinical stage,lymph node metastasis,latero-uterus or vessel infiltration,COX-2 and HPV 16-E6 are independent prognostic factors affecting the survival of patients with cervical cancer.

关 键 词：关键词 宫颈癌 环氧合酶-2 人乳头瘤病毒16-E6 预后 

分 类 号：R737.33[医药卫生—肿瘤]