血清巨噬细胞抑制因子1联合甲胎蛋白异质体3含量检测在原发性肝癌诊断中的价值  

Diagnosis value of expression of inserum macrophage inhibitory factor 1 combined with alpha-fetoprotein isoforms 3 in primary liver cancer

作　　者：刘艳红[1] 韩素桂[1] 刘洪梅[1] 高华[1] 李玉柱[1] 

机构地区：[1]河北省唐山市人民医院肿瘤医院检验科,063001

出　　处：《肿瘤研究与临床》2013年第11期742-744,共3页Cancer Research and Clinic

摘　　要：目的 探讨酶联免疫吸附（ELISA）法检测血清巨噬细胞抑制因子Ⅰ（MIC-1）联合甲胎蛋白异质体3（AFP-L3）对原发性肝癌的诊断价值.方法 选择116例临床确诊的原发性肝癌患者,应用ELISA法检测患者血清MIC-1和AFP-L3含量,分析二者联合检测在原发性肝癌诊断中的价值.结果 原发性肝癌组AFP-L3浓度为（127.12±51.43）ng/ml,明显高于正常对照组的（27.11±7.26） ng/ml（P＜ 0.001）,以AFP-L3＞ 38.0 ng/ml为临界值时,灵敏度为85.34％（99/116）,特异度为88.33％（53/60）,诊断准确度为86.36％（152/176）;原发性肝癌组MIC-1浓度为（3140.43±1138.23）pg/ml,明显高于正常对照组的（701.88±302.34） pg/ml（P＜0.001）,灵敏度为91.38％（106/116）,特异度为85.00％（51/60）,诊断准确度为89.20％（157/176）.二者联合检测灵敏度为83.62％（97/116）,特异度为91.67％（55/60）,诊断准确度为86.36％（152/176）.结论 MIC-1联合AFP-L3检测可提高原发性肝癌诊断的特异度,具有一定的临床价值.Objective Study on the diagnosis value of expression of serum macrophage inhibitory factor 1 （MIC-1） combined with alpha-fetoprotein isoforms 3 （AFP-L3） in primary liver cancer detected by enzyme linked immunosorbent assay （ELISA）.Methods MIC-1 and AFP-L3 concentrations were detected by ELISA from selected 116 patients of primary liver cancer.Results were compared both in combined and sigle detection.Results In primary liver cancer group AFP-L3 concentration [（127.12±51.43） ngmml] was significantly higher than that in normal control group [（27.11±7.26） ng/ml,P 〈 0.001].With AFP-L3 〉 38.0 ng/ml as the critical value,the sensitivity was 85.34 % （99/116）,specificity was 88.33 % （53/60） and the diagnostic accuracy was 86.36 % （152/176）.In primary liver cancer group MIC-1 concentration [（3140.43±1138.23） pg/ml]was significantly higher than that in normal the control group [（701.88±302.34） pg/ml,P 〈 0.001],the sensitivity was 91.38 % （106/116）,specificity was 85.00 % （51/60）,the diagnostic accuracy was 89.20 %（157/176）.The two combined detection sensitivity was 83.62 % （97/116）,specificity was 91.67 % （55/60）,diagnostic accuracy was 86.36 % （152/176）.Conclusion MIC-1 combined with AFP-L3 concentration detection can improve the specificity of the diagnosis of primary liver cancer,which has certain clinical value.

关 键 词：肝肿瘤 原发 巨噬细胞抑制因子 甲胎蛋白异质体 酶联免疫吸附测定 

分 类 号：R735.7[医药卫生—肿瘤]