18F—FDGPET／CT在鼻咽癌综合治疗后患者随访及预后评估中的价值  

Prognostic value of 18F-FDG PET/CT for nasopharyngeal carcinoma patients follow-up after compre- hensive therapy

作　　者：田月丽[1] 兰晓莉[1] 张永学[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院核医学科,分子影像湖北省重点实验室,武汉430022

出　　处：《国际放射医学核医学杂志》2013年第6期359-363,377,共6页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家高技术研究发展计划（863计划）项目（2008A.A022426）

摘　　要：鼻咽癌是一类发病率较高、早期发现困难、误诊误治率较高的头颈部恶性肿瘤。多数鼻咽癌患者对放疗敏感，但仍有部分患者出现残留、复发或转移。PET／CT作为现代医学影像重要组成部分之一，将PET的功能显像与CT的解剖成像有机结合，不仅能有效显示肿瘤的增生、代谢、乏氧及细胞的凋亡状态，而且能精确显示肿瘤与其周围脏器组织的解剖结构，在鼻咽癌患者的临床诊断、分期、治疗及预后评估等方面具有重要价值。该文重点就PET／CT对鼻咽癌综合治疗后患者局部残留、复发或转移的诊断价值及预后评估效能进行综述。Nasopharyngeal carcinoma （NPC）, which has high morbidity, difficult diagnosis, and poor treatment results, is a type of malignant tumor in head and neck cancer. The mainstay treatment for nasopharyngeal carcinoma has been radiotherapy as NPC is sensitive to radiotherapy. However, there is a significant rate of local failures and distant metastases. PET/CT, an important imaging modality in modern medicine, combines the functional imaging of PET and the anatomic imaging of CT to efficiently image tumor proliferation, metabolism, hypoxia and cell apoptosis. It can also precisely image the anatomic structure of tumors and their adjacent organs or tissues. PET/CT was found to be particularly helpful for guiding diagnosis and therapy, the staging and grading of tumors, monitoring therapy and in evaluating the prognosis of patients with nasopharyngeal carcinoma.

关 键 词：鼻咽肿瘤 正电子发射断层显像术 体层摄影术 x线计算机 氟脱氧葡萄糖F18 

分 类 号：R739.63[医药卫生—肿瘤]