p53、nm23和c-erbB-2蛋白在子宫内膜癌中的表达及其临床意义  

A STUDY ON EXPRESSIONS OF p53, nm23 AND c-erbB-2 IN ENDOMETRIAL CARCINOMA AND THEIR CLINICAL SIGNIFICANCE

作　　者：韦淑琴[1] 安洋[1] 庄如锦 孙云桥[1] 刘国军 

机构地区：[1]哈尔滨医科大学第一临床医学院妇产科,150001 [2]哈尔滨轻工产院,150001

出　　处：《中国现代医学杂志》2000年第10期9-11,共3页China Journal of Modern Medicine

摘　　要：目的 :研究 p5 3、nm2 3和c -erbB - 2蛋白在子宫内膜癌中的表达及其临床意义。方法 :用LSAB免疫组化法检测 42例子宫内膜癌中p5 3、nm2 3和c-erbB - 2蛋白的表达。结果 :p5 3 ,nm2 3,c -erbB - 2在子宫内膜癌中的阳性率分别为 31.0 %、6 0 .0 %、47.6 % ,其阳性表达与年龄、不同组织学类型差异无显著性 (P >0 .0 5 ) ;p5 3与病理分级有关 ,随着细胞分级的增高 ,其阳性率逐步升高 ,差异有极显著性 ( χ2 =16 .3,P <0 .0 0 5 ) ;nm2 3与病理分级呈负相关 (P <0 .0 1) ,无淋巴结转移者阳性表达率明显高于有淋巴结转移者 ( 71.9%和 2 0 .0 % ,P <0 .0 5 ) ;c -erbB - 2的表达与癌细胞的分化程度、临床分期有关 ,分化程度高及早期癌中c -erbB - 2表达强。结论 :对子宫内膜癌进行p5 3、nm2 3和c -erbB - 2蛋白的检测 ,有助于预测子宫内膜癌的发生、演进、转移和预后。Objective: To investigate the expressions of p53, nm23 and c-erbB-2 in endometrial carcinoma and their clinical significance. Methods: 42 cases of endometrial carcinoma were studied by immunohistochemical technique (LSAB). Results: The posotive rats of p53, nm23 and c-erbB-2 were 31.0%, 60% and 47.6% respectively. Positive expression did not relate to age, histological type ( P >0.05); p53 was significantly associated with pathological grade, the positive rate rise with cell grade progress, clinical stage (χ 2=16.3, P <0.005). nm23 was negative related to pathological grade ( P <0.01), the positive rate of nm23 with lymphocyte metastasis was significantly lower non-metastasis (20.0%, 71.9%, P <0.05); The expression of c-erbB-2 was associated with pathological grade and clinical stage, the positive rate was higher in G1 grade and early stage carcinoma. Conclusions: The detection of p53, nm23 and c-erbB-2 oncoproteins might be helpful to predict the progress, metastasis and prognosis of endometrial carcinoma.

关 键 词：子宫内膜肿瘤 P53蛋白 NM23蛋白 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]