固相萃取-气相色谱-质谱联用法测定白术中8种有机氯农药的残留量  

Determination of 8 Organochlorine Pesticides in Atractylodes Macrocephala by SPE-GCMS

作　　者：翟枫 金立弟 戴博 周敏[2] 

机构地区：[1]吉林市食品药品检验所,吉林吉林132000 [2]空军总医院药学部,北京100142

出　　处：《中国医院用药评价与分析》2013年第10期914-917,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的：建立固相萃取-气相色谱-质谱联用法同时测定白术中8种有机氯农药残留量。方法：样品以丙酮超声提取,采用氨基固相萃取柱进行净化,气相色谱-质谱联用技术进行测定。结果：8种有机氯农药在10~1 000μg/L范围内呈良好的线性关系,8种农药的检测限在0.3~2.0μg/kg之间,定量限在1.0~6.0μg/kg之间,3个水平添加回收率在82.07%~105.13%之间,相对标准偏差（RSD）〈6%（n=9）。结论：本方法灵敏度高,重现性好,可用于白术中8种有机氯农药残留量的检测。OBJECTIVE：To establish an SPE-GC-MS （Solid Phase Extraction-Gas Chromatography-Mass Spectrometry） method for the simultaneously determination of 8 organoehlorine pesticides in Atractylodes Macrocephala. METHODS： The sample was extracted ultrasonically using acetone, purified using NH2-solid phase extraction column and determined by GC-MS. RESULTS： The linear range of the 8 organochlorine pesticides was 10-1 000 μg/L, and their limits of detection （LOD） ranged within 0. 3-2. 0μg/kg and limits of quantitation （LOQ） ranged at 1.0-6.0μg/kg. The average fortified recovery rates at three levels ranged at 82.07%-105.13% with relative standard deviations （RSD） less than 6% （n = 9 ）. CONCLUSION： The method is sensitive and reproducible and it can be used for the detection of pesticide residues of 8 organochlorine in Atractylodes Macrocephala.

关 键 词：氨基固相萃取 气相色谱-质谱 白术 有机氯农药 

分 类 号：R965[医药卫生—药理学]