中药抗乳腺癌骨转移实验研究进展  

Study Progress on Breast Cancer Metastasis to Bone Treated with Chinese Herbs

作　　者：张小慧[1,2] 韩向晖[1] 刘胜[1] 王春丽[2] 

机构地区：[1]上海中医药大学附属龙华医院中医外科研究所,上海200032 [2]华东理工大学中药现代化工程研究中心,上海200237

出　　处：《世界科学技术-中医药现代化》2013年第6期1447-1450,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然基金委青年基金项目(81102598):"温肾壮骨法"影响乳腺癌骨转移间充质干细胞与肿瘤细胞相互作用的机制研究;负责人:韩向晖;上海中医药大学附属龙华医院"龙医团队;龙医学者"(培育)计划(LYTD-17):中药复方在乳腺癌骨转移模型中的PK-PD联合研究;负责人:韩向晖

摘　　要：骨是乳腺癌常见的转移部位,乳腺癌骨转移可导致骨质疏松、高血钙症、脊髓压迫和病理性骨折等并发症,严重影响患者的生活和生存质量。中医中药在治疗乳腺癌骨转移方面显示出潜在的优势。近10年研究发现,许多中药单体、提取物以及中药复方能够从不同分子机制发挥抑制乳腺癌细胞增殖、侵袭,缓解乳腺癌细胞引起的骨质破坏及癌性骨痛作用。Bone is the most common metastatic site of breast cancer . And breast cancer metastasis to bone can lead to osteoporosis , hypercalcemia , spinal cord compression and pathological fracture , which seriously impact the patientsˊ quality of life and survival . Chinese herbs have a potential advantage in the treatment of breast cancer metastasis to bone. In recent ten years, a number of studies showed that Chinese medicine monomers, traditional Chinese medicine （TCM） extracts, and Chinese herbal compound prescriptions played a role in in-hibiting breast cancer cell proliferation , invading and relieving the bone destruction and bone pain by different molecular mechanisms .

关 键 词：乳腺癌 骨转移 中药 分子机制 综述 

分 类 号：R737.9[医药卫生—肿瘤]