系统生物学——非酒精性脂肪性肝病中医药研究的新途径  

Systems Biology——New Approach for Study on Non-alcoholic Fatty Liver Disease with Traditional Chinese Medicine

作　　者：孟胜喜[1] 胡义扬[1,2,3] 冯琴[1] 彭景华[1] 

机构地区：[1]上海中医药大学附属曙光医院肝病研究所,上海201203 [2]上海市高校中医内科学E-研究院,上海201203 [3]上海市中医临床重点实验室,上海201203

出　　处：《世界科学技术-中医药现代化》2013年第7期1521-1525,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委面上项目(81173404):基于肝脂肪代谢环节的中药组分"BZL"复方防治非酒精性脂肪肝作用机理研究;负责人:胡义扬;国家自然科学基金委面上项目(81384031):基于GLP-1受体相关信号通路的京尼平苷与绿原酸组合治疗非酒精性脂肪肝效应机制研究;负责人:冯琴;上海自然科学基金委项目(13ZR1442600):基于GLP-1受体相关信号通路的中药组分复方GC方防治非酒精性脂肪肝的机理研究;负责人:冯琴

摘　　要：系统生物学是系统论与生物学的结合。它包括基因组学、蛋白质组学、转录组学和代谢组学等。利用系统论的思维方法研究生命现象,从多学科、多视角认识中医证候和中医药疗效机制,为中医研究提供了重要的方法学基础和技术条件;系统生物学与中医学系统观和整体观念的核心思想不谋而合。因此,将系统生物学作为非酒精性脂肪性肝病(NAFLD)的现代中医药研究平台和支点,必将加速中医药防治NAFLD的现代化研究,也为中医药研究NAFLD提供新思路和新途径。Systems biology, which includes genomics, proteomics, transcriptomics and metabolomics, is an integration of system theory and biology. It studies the life phenomena with thinking method of systems theory. And it provides an important methodological basis and technical conditions for recognizing syndrome of traditional Chinese medicine （TCM） and mechanism of therapeutic effect from multiple disciplines and perspectives. Systems biology is similar to the core idea of TCM system and holism concept. Therefore, systems biology can be used as a platform and pivot of non-alcoholic fatty liver disease （NAFLD） in modern TCM study. Systems biology will accelerate the modernization research of TCM in the prevention and treatment of NAFLD. It will also provide new ideas and methods for TCM study on NAFLD.

关 键 词：系统生物学 中医药 非酒精性脂肪性肝病 

分 类 号：R242[医药卫生—中医临床基础]