程序性细胞死亡分子5(PDCD5)在细胞凋亡中的作用及应用前景  

The effect and application of programmed cell death 5(PDCD5)in the regulation of apoptosis

作　　者：令狐丹丹 陈春花[2] 

机构地区：[1]北京大学医学部基础医学院临床医学系,北京100191 [2]北京大学医学部解剖与组织胚胎学系,北京100191

出　　处：《解剖科学进展》2013年第6期571-573,575,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金资助项目(No.81000523)

摘　　要：程序性细胞死亡分子5(Programmed Cell Death 5,PDCD5)作为一种重要的凋亡正调控分子,在许多疾病的发生发展过程中起着重要作用。PDCD5本身不具有诱导凋亡的作用,但在诱导凋亡因素(如撤除细胞因子、撤除血清、化疗药物处理等)存在时,可明显促进细胞凋亡,这表明PDCD5不是凋亡诱导剂而是凋亡促进剂。随着程序化细胞凋亡正调节分子PDCD5的发现,很多学者围绕PDCD5的结构、PDCD5促进细胞凋亡的机制、PDCD5与某些疾病发生发展的关系、以及PDCD5在临床工作中的应用等方面进行了研究,本文将对这些研究成果进行归纳整理,重点阐述PDCD5与肿瘤发生发展以及肿瘤治疗的关系。Programmed cell death 5 （PDCD5） is an important molecule related to apoptosis and plays important roles in the process of many diseases. The PDCD5 itself does not induce apoptosis, but in the presence of apoptosis factors（such as removal of cytokines, serum deprivation, chemotherapy treatment）, can promote apoptosis obviously, which suggests that PDCD5 is not an apoptosis inducer but promoter. With the discovery of this gene, many scholars in this field foeuse on the structure of PDCD5, the relationship of PDCD5 and some diseases, as well as the application of PDCD5 in clinical work. In the description of the relationship between PDCD5 and diseases, we would highlight PDCD5 with tumor development, give a brief description of the latest research trends.

关 键 词：促进细胞凋亡 程序性细胞死亡 调控分子 肿瘤发生发展 PDCD5 诱导凋亡 Death 凋亡诱导剂 

分 类 号：R730.21[医药卫生—肿瘤]