杭州地区2151例羊水染色体检查结果分析  

Analysis of the prenatal diagnosis result of 2151 pregnant woman in Hangzhou

作　　者：王昊[1] 汪燕[1] 孙博[1] 王雪方[1] 

机构地区：[1]杭州市第一人民医院中心实验室,浙江杭州310006

出　　处：《中国优生与遗传杂志》2013年第11期32-33,23,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨孕中期羊水细胞染色体分析在产前诊断胎儿染色体异常中的价值。方法选取杭州地区2009年10月至2012年12月在杭州市第一人民医院产前诊断中心行羊水穿刺的2151例妊娠19-26周孕妇,行羊膜腔穿刺,取羊水细胞进行培养,常规收获,显带,并作核型分析。结果成功培养的2084例羊水染色体中,共检出异常核型77例,检出率为3.69%,检出多态172例,检出率为8.25%。不同年龄组孕妇间染色体异常检出率比较无统计学差异(P>0.05)。结论孕中期羊水细胞染色体核型分析安全,有效,可靠,是产前诊断的重要手段。Objective ： To discuss the value of amniocentesis and karyotype in prenatal diagnosis of fetal chromosome abnormality. Methods： 2151 pregnant woman in Hangzhou city with high risk of fetal chromosome abnormal were performed amniocentesis and prena- tal diagnosis, result of the karyotype were collected and analysed. Results： There were 77 chromosome abnormal and 172 chromosome polymorphism cases in all 2084 cases. There is no significance difference between those with high maternal age and with high risk result of prenatal screening. Conclusion： Amniocentesis and fetal cell chromosome analysis is a safe, efficient, and reliability method to preg- nant woman in second trimester with risk of chromosomal abnormality.

关 键 词：产前诊断 羊膜腔穿刺 核型分析 染色体 

分 类 号：R714.55[医药卫生—妇产科学]