姐弟同患骨髓增殖性疾病2例并文献复习  

Two cases of siblings with myeloproliferative disease and literature review

作　　者：庞宇慧[1] 高习华 李建英[1] 武大勇[1] 刘清池[1] 

机构地区：[1]石家庄平安医院血液科,石家庄050021

出　　处：《临床血液学杂志》2013年第6期801-803,共3页Journal of Clinical Hematology

摘　　要：骨髓增殖性疾病（myelopr01iferativediseases，MPD）是一组多能造血干细胞的克隆性疾病，表现为一系或多系骨髓细胞的异常增殖。MPD在欧美国家中并不少见，总的发生率为6～10／（10万人口·年），好发于50岁以上的中老年人，男性多见，而在我国尚无可靠的流行病学调查。随着JAK2V617F等基因突变的发现，Summary Two cases of fellow siblings with myeloproliferative neoplasms were admitted. The sister was di- agnosed with overlap syndrome （essential thrombocythemia and myelofibrosis） and the brother was diagnosed with myelofibrosis. Now we will review the incidence, pathogenesis, clinical features and prognosis of familial myelopro- liferative neoplasms.

关 键 词：骨髓增殖性疾病 家族性 

分 类 号：R551.3[医药卫生—血液循环系统疾病]