淋巴增强因子-1与肺癌侵袭、转移的相关性研究  

Correlation between LEF-1 Expression and the Invasion and Metastasis of Lung Cancer

作　　者：穆德广[1] 金发光[1] 谢永宏[1] 傅恩清[1] 李春梅[1] 马李杰[1] 

机构地区：[1]第四军医大学唐都医院呼吸与危重症学科,陕西西安710038

出　　处：《现代生物医学进展》2013年第28期5460-5462,共3页Progress in Modern Biomedicine

基　　金：陕西省卫生厅基金项目(2010E05);陕西省科技厅社发攻关项目(2011K13-03-01)

摘　　要：目的:探讨淋巴增强因子-1(LEF-1)在肺癌组织中的表达及其与肺癌侵袭转移的关系。方法:利用免疫组化技术检测不同病理分期患者石蜡切片组织中LEF1的表达。利用real-time PCR检测不同部位组织LEF-1基因表达状况。结果:分期差的患者肺癌组织有LEF1较高水平表达。转移淋巴结组织较肿瘤组织中的LEF-1基因表达水平高。肿瘤组织较周边正常组织中的LEF-1基因表达水平高。结论:LEF-1与肺癌细胞侵袭、转移密切相关。进一步深入研究,将有助于阐明肿瘤侵袭、转移机制,为肿瘤治疗提供新的线索。Objective： To explore the expression of Lymphatic Enhancement Factor 1 （LEF-1） in the lung tissue and its relationship with the invasion and metastasis of lung cancer. Methods： We detected the expression of LEF-1 in lung tissues from lung cancer patients of different pathological stages by using immtmohistochemical technique and determined LEF-1 gene expression in tissues from different location. Results： Relative up-regulation of LEF-1 was detected in patients of late stage; the expression of LEF-1 in metastatic lymph nodes was higher than that of lung tumor tissue, and LEF-1 in normal tissue surrounding the tumor was also increased. Conclusion： LEF-1 was closely related to the invasion and metastasis of lung cancer cells. Therefore, further study of LEF-1 will provide new clinical clues for tumor treatment through helping to elucidate the mechanism of tumor invasion and transfer.

关 键 词：淋巴增强因子-1 肺癌 侵袭 转移 

分 类 号：R734.2[医药卫生—肿瘤]