莫沙必利在胶囊内镜检查中应用的系统评价  

Effect of mosapride on capsule endoscopy: A systematic review of randomized controlled trials

作　　者：何继东[1] 王一平[2] 张兰[1] 杨秀蓉[1] 

机构地区：[1]雅安市第二人民医院消化内科,四川省雅安市625000 [2]四川大学华西医院消化科,四川省成都市610041

出　　处：《世界华人消化杂志》2013年第32期3602-3607,共6页World Chinese Journal of Digestology

摘　　要：目的:系统评价莫沙必利在胶囊内镜检查中应用的有效性和安全性.方法:计算机全面检索Cochrane图书馆临床对照试验数据库(2013-01)、MEDLINE或PubMed(1978-2013)、Ovid(1978-2013)、维普中刊数据库(1989-2013)、中国期刊全文数据库(1979-2013)等.手工检索《中华消化杂志》等4种相关中文期刊、相关会议论文集及所有检索到文献的参考文献.按Cochrane协作网推荐的方法进行系统评价.结果:共纳入7个RCT(包括500例患者).Meta分析结果显示:(1)胃排空时间:莫沙必利组优于空白对照(P<0.00001);(2)小肠通过时间:莫沙必利组优于空白对照(P<0.00001);(3)小肠检查完成率:莫沙必利组优于空白对照(P<0.00001);(4)胶囊内镜诊断率:莫沙必利组不优于空白对照(P=0.05).结论:基于目前的证据,我们认为,胶囊内镜检查前口服莫沙必利能缩短胃排空时间,提高小肠检查完成率,但上述结果解释应慎重,有待进一步循证医学的证据.AIM： To assess the effect of mosapride on cap- sule endoscopy. METHODS： We searched Cochrane Central Register of Controlled Trails （CENTRAL）, MED- LINE or PubMed, and Chinese VIP database. The bibliographies of retrieved articles and cor- related proceedings were also searched manu- ally. A systematic review was conducted using the method recommended by the Cochrane Col- laboration. RESULTS： Seven trials involving 500 patients were included in the systematic review. Meta- analysis showed that mosapride was superior to the blank control in terms of gastric emptying time （P 〈 0.00001）, small-bowel transit time （P 〈 0.00001） and the completion rate of small bowel examination （P 〈 0.00001）; however, mosapridewas not superior to the blank control in the di- agnostic yield （P= 0.05）. CONCLUSION： The limited current evidence shows that mosapride decreases gastric empty- ing time and improves the completion rate of total small-bowel examination in patients un- dergoing capsule endoscopy. However, all these findings should be interpreted with caution and more clinical trials are needed.

关 键 词：莫沙必利 胶囊内镜 系统评价 META分析 

分 类 号：R57[医药卫生—消化系统]