遗传性非息肉病性大肠癌七个家系21例分析  

Hereditary nonpolyposis colorectal cancer:a report of 21 cases from 7 families

作　　者：王石林[1] 丁映钦[1] 魏学明[1] 欧阳筥玺[1] 顾国利[1] 

机构地区：[1]空军总医院普通外科,北京100036

出　　处：《中华普通外科杂志》2000年第11期667-668,共2页Chinese Journal of General Surgery

摘　　要：目的　提高对遗传性非息肉病性大肠癌临床特性、诊断和治疗的认识。方法　对 7个有遗传性非息肉病性大肠癌家系进行调查。结果　 7家系中有 2 1例发病者 ,年龄 2 6～ 79岁 ,平均年龄 46岁。 2 1例共有 31处大肠癌灶 ,其中 16处位于脾曲近端的大肠 ,10处位于脾曲远端的大肠 ,5处部位不详。 6 1 5 % (16 /2 6 )的癌灶位于脾曲近端的大肠。 6例患大肠多原发癌 ,占全组的 2 8 6 % (6 /2 1)。结论　对遗传性非息肉病性大肠癌患者及其家系成员要进行严密监测 ,争取早诊断早治疗 ,提高治疗效果。Objective For better recognition of the hereditary nonpolyposis colorectal cancer (HNPCC) with reference to its clinical characteristics, diagnosis and treatment [WT5”HZ]Methods [WT5”BZ] A survey of 7 families of HNPCC patients was made [WT5”HZ] Results [WT5”BZ]Among the 7 families, 21 persons had colorectal cancer with age ranging from 26 to 79 years (average 46 years) The total of the colorectal cancer foci in 21 cases were 31,among which 16 were located proximal to,10 distal to the splenic flexure and 5 without definite record 61 5%(16/26) of the colorectal cancer foci were located proximal to the splenic flexure Six patients had multifocal colorectal cancer, which accounted for 28 6%(6/21) of all cases [WT5”HZ] Conclusions [WT5”BZ] HNPCC patients and their family members should be followed up regularly for early diagnosis and treatment of the disease and for better prognosis

关 键 词：结肠直肠肿瘤 遗传性非息肉性 诊断 

分 类 号：R735.34[医药卫生—肿瘤]