核酸药物及其给药系统用于炎症性肠病治疗的研究进展  

Research Advances in Nucleic Acid Drugs and Related Delivery Systems for the Treatment of Inlammatory Bowel Disease

作　　者：赵然[1] 黄振[1] 陈江宁[1] 张峻峰[1] 

机构地区：[1]南京大学生命科学学院医药生物技术国家重点实验室,江苏南京210093

出　　处：《药学进展》2013年第11期574-579,共6页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金项目(No.31071232;No.31170751;No.51173076;No.91129712);国家杰出青年科学基金项目(No.81025019)

摘　　要：炎症性肠病是一种常见的免疫功能紊乱所致慢性顽固性胃肠道炎性疾病,现有的治疗手段难以根治。随着炎症性肠病分子机制研究的不断深入,在基因水平上应用核酸药物及其给药系统,对炎症性肠病发挥的独特治疗作用,已受到越来越多的关注,并取得一定进展。本文简介炎症性肠病的发病机制,综述近年来核酸药物及其给药系统用于炎症性肠病治疗的研究进展。Inflammatory bowel disease （IBD） is one of common chronic refractory gastrointestinal inflammatory diseases, a immune dysthnction disease which could hardly be eradicated with currently available therapies. With the understanding of molecular mechanism involved in IBD, nucleic acid drugs and related delivery systems used for the IBD treatment at the genetic level have received increasing attention and also certain achievements have been made. The pathogenesis of IBD was briefly introduced and the recent research advances in nucleic acid drugs and related delivery systems for the IBD treatment were reviewed.

关 键 词：炎症性肠病 核酸药物 基因调控 靶向给药系统 

分 类 号：R574.62[医药卫生—消化系统] Q756[医药卫生—内科学]