不同多孔PLGA/纳米羟基磷灰石复合支架加载辛伐他汀药物释放性能的研究  

Study on Dissolution Rates of Different Simvastatin Loaded Porous PLGA/Nano Hydroxyapatite Composite Scaffold Materials

作　　者：胡飞[1] 周磊[1] 周东风[1] 吴王喜[1] 

机构地区：[1]广东省口腔医院,广东广州510280

出　　处：《临床医学工程》2013年第12期1480-1481,共2页Clinical Medicine & Engineering

基　　金：广东省自然科学基金(9151008901000028)

摘　　要：目的研究不同多孔PLGA／纳米羟基磷灰石复合支架加载辛伐他汀的药物释放性能。方法采用PLGA颗粒和纳米羟基磷灰石颗粒为原料，制备五种加载辛伐他汀的复合支架材料，并用分光光度仪测定每种复合支架材料辛伐他汀释放情况。结果加载辛伐他汀的五种类型复合支架，体外药物释放均呈缓慢持续性释放达到60d以上，60天累积释放率达70～90％，其中采用产气颗粒沥析技术的两种支架材料释放速度较为均衡。结论加载辛伐他汀的多孔PLGA／纳米羟基磷灰石复合支架具有良好的药物释放性能。Objective To study the dissolution rates of different simvastatin loaded porous PLGA/nano hydroxyapatite composite scaffold materials. Methods PLGA particles and nano HA particles were used to make different simvastatin loaded porous PLGA/nano hydroxyapatite. The dissolution rates of simvastatin were studied. Results Five materials had a dramatic slow releasing efficiency more than 60 days. Among them, the materials made of gas-produced Particulate leaching technology got better releasing efficiency. Conclusions The simvastatin loaded by Porous PLGA/nano hydroxyapatite composite scaffold material has good releasing efficiency.

关 键 词：多孔PLGA 辛伐他汀 羟基磷灰石 

分 类 号：R783.1[医药卫生—口腔医学]