前列腺特异性抗原在诊断前列腺癌中的临床意义  

Clinical Significance of Prostate Specific Antigen in The Diagnosis of Prostatic Cancer

作　　者：苏秀琼[1] 任蓬程 郑岗[1] 王小勇[1] 

机构地区：[1]广东省惠州市中医医院检验科,广东惠州516001

出　　处：《临床医学工程》2013年第12期1498-1499,共2页Clinical Medicine & Engineering

基　　金：惠州市科技计划项目(2010Y057)

摘　　要：目的探讨前列腺特异性抗原(PSA)在诊断前列腺癌中的临床价值。方法选择84例直肠指检可疑前列腺癌的患者进行前列腺穿刺活检,其中确诊为前列腺癌的52例为观察组,确诊为良性前列腺增生的32例为对照组,分别对两组进行血清PSA检测,并计算PSAD及PSAD-TZ。结果观察组PSA、PSAD、PSAD-TZ水平均明显高于对照组,差异均有统计学意义(P<0.05)。ROC曲线AUC面积PSA>PSAD>PSAD-TZ,若以PSA≥4.38 ng/mL为截点诊断前列腺癌,其敏感度为82.3%、特异性为54.2%;若以PSAD≥5.19 ng×mL2来诊断前列腺癌,其诊断敏感度为61.5%、特异性为52.1%。结论 PSA与PSAD联合能提高诊断前列腺癌的敏感度和特异性。Objective To explore the clinical significance of prostate specific antigen （PSA） in the diagnosis of prostate cancer. Methods Prostate biopsy was performed in 84 cases of patients suspected with prostate cancer after rectal examination. Among them, 52 cases confirmed with prostate cancer were divided into the observation group; 32 cases diagnosed as benign prostatic hyperplasia were divided into the control group, serum level of PSA was measured, and the PSAD and PSAD-TZ were calculate in two groups. Results PSA, PSAD, PSAD-TZ levels were significantly higher in the observation group than those in the control group （P 〈0.05）. The ROC curve of AUC area ofPSA 〉PSAD 〉PSAD-TZ; ifPSA ≥4.38 ng/mLwas as the cut-offpoint for diagnosis of prostate cancer, the sensitivity was 82.3%, and specificity was 54.2%; ifPSAD ≥ 5.19 ng × mL2 was used to diagnose prostate cancer, the diagnostic sensitivity was 61.5%, specificity was 52.1%. Conclusions PSA combined with PSAD can improve the sensitivity and specificity for the diagnosis of prostate cancer.

关 键 词：前列腺癌 前列腺特异性抗原 ROC曲线 

分 类 号：R73[医药卫生—肿瘤]