西维因环境内分泌干扰效应的非受体介导作用机制研究进展  

Non-receptor-mediated action mechanisms of endocrine disrupt effect in carbaryl environ-ment.

作　　者：李文婷[1] 宋超[2] 吕钊[1] 刘颖 冯嘉林 陈家长[1,2] 

机构地区：[1]南京农业大学无锡渔业学院,江苏无锡214081 [2]中国水产科学研究院淡水渔业研究中心,江苏无锡214081 [3]无锡市动物疫病控制中心,江苏无锡214000

出　　处：《生态学杂志》2013年第12期3385-3391,共7页Chinese Journal of Ecology

基　　金：中央级公益性科研院所基本科研业务费专项(2013JBFM05);现代农业产业技术体系建设专项(CARS-49)资助

摘　　要：西维因作为广泛使用的氨基甲酸酯类杀虫剂,不仅具有抑制乙酰胆碱酯酶活性的神经毒性,其内分泌干扰效应也备受关注。环境激素的内分泌干扰效应主要是通过对脑-脑垂体-性腺轴(HPG)产生作用。本文在此基础上,进一步阐述了西维因对HPG轴中性腺类固醇激素合成途径产生影响的非受体介导的内分泌干扰机制,且表现为雌激素效应。本文为深刻认识环境激素对动物的生殖、生理活动,以及理解氨基甲酸酯类杀虫剂的神经内分泌免疫行为提供了参考。As the most worldwide applied carbamates insecticide, carba~~l not only has the neu- rotoxic effect in inhibiting the activity of aeetylcholinesterase, but also has the endocrine disrupt effect. The endocrine disrupt effect of environmental hormones is mainly produced by regulating the molecular expression of hypothalamus-pituitary-gonad axis （HPG）. This paper further eluci- dated the non-receptor-mediated action mechanisms under the effects of carbaryl on the pathways of the steroid hormone synthesis of gonad, an important sector of HPG axis, and indicated that these non-receptor-mediated action mechanisms were the sequent results of estrogen effect. This paper would provide a reference to understand the effects of environmental hormones on the repro- duction and physiology of animals, and the neuro-endocrine immune effect of carbamates insecti- cides.

关 键 词：西维因 环境内分泌干扰物 非受体介导 

分 类 号：X171.5[环境科学与工程—环境科学]