以乙肝病毒核衣壳为靶标的二氢嘧啶类化合物及其作用机制研究进展  

Research on anti-HBV mechanism of HAPs targeting on HBV capsid

作　　者：杨秀岩[1,2] 赵国明[2] 李松[2] 

机构地区：[1]沈阳药科大学制药工程学院,辽宁沈阳110016 [2]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国药物化学杂志》2013年第6期493-498,共6页Chinese Journal of Medicinal Chemistry

基　　金：国家自然科学基金项目(21172263)

摘　　要：核衣壳是乙肝病毒(HBV)的核心结构,在HBV复制感染中起到了重要作用。以核衣壳为靶标的二氢嘧啶类化合物(HAPs)是一类全新结构的高活性HBV抑制剂,有望成为一种新型的乙型肝炎治疗药物。本文就HAPs类化合物的结构特点及其抗乙肝作用机制的研究进展进行综述。The capsid as a core structure of HBV is key to complete the viral life cycle and infection. Het- eroaryldihydropyrimidines（HAPs） targeting on viral capsid was discovered as highly potent and new struc- ture inhibitors of HBV replication in vitro and in vivo, which would be a new kind of anti-HBV drugs. Re- searching on the anti-HBV mechanism of HAPs can benefit to find more effective and safe drugs. In this re- view the progress on the structure of HAPs and the anti-HBV mechanism of HAPs were summarized.

关 键 词：乙型肝炎病毒 杂环二氢嘧啶类化合物 核衣壳 作用机制 

分 类 号：R914[医药卫生—药物化学]