岩舒联合EP方案治疗小细胞肺癌的疗效观察  

Efficacy Observation of Yanshu Injection Combined with Chemotherapy for Small Cell Lung Cancer

作　　者：陈鲁琦[1] 王伟丽[1] 张春艳[1] 侯聪霞[1] 彭成丽[1] 

机构地区：[1]河南省胸科医院,河南郑州450003

出　　处：《辽宁中医杂志》2013年第12期2514-2516,共3页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:观察岩舒(复方苦参注射液)联合EP方案治疗小细胞肺癌(SCLC)的临床疗效。方法:60例小细胞肺癌患者随机分成试验组及对照组。试验组30例采用岩舒联合EP方案全身化疗,对照组单纯采用EP方案全身化疗。2组化疗均4周为1个周期,至少四周期,在第2周期结束时评价疗效。结果:试验组和对照组的有效率分别为76.7%和70.0%(P>0.05),试验组骨髓抑制、消化道反应较对照组轻(P<0.05)。试验组生存质量明显高于对照组(P<0.05)。试验组和对照组中位生存期分别为440天和288天(P<0.05)。结论:岩舒联合EP方案治疗小细胞肺癌疗效确切,不良反应轻,具有提高中位生存期,改善患者生活质量的作用。Objective ： To observe the clinical efficacy of Yanshu Injection （ Compound Kusheng Injection） combined with EP regimen chemotherapy for the treatment of sn~], cell lung cancer （SCLC）. Methods ： 60 cases of small cell lung cancer patients were randomly divided into experimental group and control group. 30 patients in experimental group were treatment with Yanshu Injection combined with EP regimen chem6erapy. 30 patients in control group received EP regimen chemotherapy alone. Both regimens were repeated every 4 weeks and at least 4 cycles All patients completed efficacy evaluation after treatment 2 cycles. Re sults ： The effective rates of experimental group and control group were 76.7% and 70.0% （P 〉 0.05）. The gastrointestinal reac tions and bone marrow depression in experimental group were alleviated compared with those in control group. There was signifi cant difference between 2 groups （P 〈 0. 05 ）. The median survival time was 440 d in experimental group while 288 d in control group（ P 〈 0. 05 ）. KPS score after chemotherapy in all experiment groups was significantly higher than that in control group（P 〈 0. 05）. Conclusion：Yanshu Injection combine with EP regimen to treat small cell lung cancer shows precise therapeutic effect on SCLC, reducing adverse drug reactions, increasing median urvival time and improving the quality of life.

关 键 词：岩舒 化疗 小细胞肺癌 EP 

分 类 号：R734.2[医药卫生—肿瘤]