凝血四项与D-二聚体检测在肝硬化患者中的临床观察分析  

Clinical significance of four coagulation tests and D-dimer test in liver cirrhosis patients

作　　者：邓芝云[1] 张艳[1] 肖娜娜[1] 林静[1] 哈小琴[1] 张方信[2] 

机构地区：[1]兰州军区兰州总医院检验科,甘肃兰州730050 [2]兰州军区兰州总医院消化内科,甘肃兰州730050

出　　处：《西北国防医学杂志》2013年第6期519-520,共2页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的:探讨肝硬化患者血凝四项指标和D-二聚体变化与临床的关系。方法:采用希森美康5100全自动血凝仪对216例肝硬化患者(Child–Pugh分级:A级62例,B级88例,C级66例)和84例健康体检者进行血凝四项和D-二聚体的检测。结果:与正常对照组相比,肝硬化各组PT、APTT、TT均明显延长(P<0.05),FIB明显降低(P<0.05),D-二聚体明显升高(P<0.05)。结论:血凝四项、D-二聚体的水平与肝硬化的严重程度密切相关,联合检测血凝四项、D-二聚体对肝硬化患者病情程度的评估、出血防治和预后判断具有重要的指导参考价值。Objective：To investigate the clinical applications of four coagulation tests and D - dimer test in pa- tients with liver cirrhosis. Methods： Four coagulation tests and the D -dimer test were performed in 216 patients with liver cirrhosis （62 in Child - Pugh A group, 88 in B group and 66 in C group） and 84 healthy individuals by Sysmex Cs -5100 auto blood coagulation analyzer. Results：Compared with the control group, the prothrombin time （PT）, activated partial thromboplastin time （AFIT） and thrombin time （TT） in liver cirrhosis group were signifi- cantly prolonged （ P 〈 0.05 ）, the fibrinogen （FIB） was significantly lower （ P 〈 0.05 ）, and the D - dimer level was significantly higher （P 〈 0.05 ）. Conclusion： The four blood coagulation indexes and serum D -dimer level are correlated with disease status of liver cirrhosis. The combination detection of blood coagulation function and ser- um D - dimer may be significantly useful for the assessment of disease condition, the treatment and prevention hemorrhage in upper digestive tract and the prediction of prognosis for cirrhosis patients.

关 键 词：肝硬化 凝血四项 D-二聚体 

分 类 号：R575.2[医药卫生—消化系统]