失眠患者氯硝西泮梯度撤药情况分析  

Analysis of clonazepam gradient withdrawal in insomnia patients

作　　者：宋钟娟[1] 周海峰[1] 高宁舟[1] 沈杰[1] 张云轩[1] 

机构地区：[1]复旦大学附属华东医院药剂科,上海200040

出　　处：《中国临床药学杂志》2013年第6期366-368,共3页Chinese Journal of Clinical Pharmacy

摘　　要：目的探索合理有效的氯硝西泮撤药方案。方法收集2010至2011年来我院失眠整合门诊就诊的使用氯硝西泮治疗失眠并成功撤药的患者的相关信息,采用SPSS 19.0软件进行统计分析。结果患者对药物剂量的关注度和撤药前的起始剂量影响撤药速度(P<0.05)。结论氯硝西泮撤药时需考虑患者的个性,敏感者的撤药速率要缓慢;在氯硝西泮起始剂量较大时可以采取减量幅度较大的方案,当减量至一定程度(每日剂量<0.5片)时需要缓慢调整用量,或者根据患者的实际情况采取延长调整周期的措施。AIM To explore the rational and effective clonazepam withdrawal program. METHODS The related information of insomnia treatment of out-patient and the successful withdrawal with clonazepam from 2010 to 2011 in our hospital was recorded, using SPSS 19.0 software for statistical analysis. RESULTS Patient＇s attention for the drug dos- es and starting withdrawal doses affected the withdrawal speed（ P 〈0. 05）. CONCLUSION The patient＇ s personality should be considered for clonazepam withdrawal. Withdrawal rate of sensitive patients should slow. In the last period clonazepam larger doses can be used for a larger reduction efforts. When the doses were reduced to some extent （daily dose of 〈 0.5 tablet ） clonazepam doses need to be more cautious in the slow adjustment, or extend the adjustment period according to the actual situation of patients.

关 键 词：失眠 氯硝西泮 梯度撤药 

分 类 号：R740[医药卫生—神经病学与精神病学]