43例合并腔梗的局限期小细胞肺癌预防性脑照射时联合银杏达莫注射液治疗的临床研究  

Clinical observation of Yinxingdamo injection in the treatment of prophylactic cranical irradiation for limited stage small cell lung cancer with lacunorinfacts

作　　者：刘晖杰[1] 阮云丹[1] 许华[1] 

机构地区：[1]华中科技大学附属襄阳市中心医院肿瘤科,湖北襄阳441021

出　　处：《现代肿瘤医学》2013年第12期2729-2731,共3页Journal of Modern Oncology

摘　　要：目的:观察合并腔梗的局限期小细胞肺癌预防性脑照射时联合银杏达莫注射液治疗的临床疗效。方法:43例合并腔梗的局限期小细胞肺癌经过化疗+放疗序贯治疗后达到完全缓解,4-8周内均进行预防性双侧全脑照射,剂量DT 25Gy/(10f·2w),分次剂量DT 2.5Gy。期间将其随机分成两组,治疗组23例预防性全脑照射同时合用银杏达莫注射液25ml加0.9%氯化钠注射液250ml静脉滴注,每日1次,连用2周;对照组20例仅做预防性全脑照射。结果:临床疗效及血液流变学检查,治疗组明显好于对照组,两组比较差异有统计学意义(P<0.05)。结论:银杏达莫注射液在合并腔梗的局限期小细胞肺癌预防性脑照射时是安全有效的。Objective：To evaluate the effects of Yinxingdamo injection in the treatment of prophylactic cranical ir- radiation （PCI） for limited stage small cell lung cancer（ SCLC ）with lacunorinfaets. Methods：A total of 43 patients with limited stage small cell lung cancer and lacunorinfacts were eompeleted remission（CR） after ehemoradiotherapy, and then,these patients received PCI in 4 -8 weeks for dose of 25Gy/（ 10f ~ 2w）,2.5Gy per fraction. 43 patients with lacunorinfaets and limited stage small cell lung cancer in CR were randomly divided into two groups. The treated group was treated with PCI and Yinxingdamo injection 25ml ＋ 0.9% Natrii ehrolide 250ml iv drip, qd,2 weeks;the control group was treated with PCI. Results：Clinical efficacy and hemorheology in examination in treatment group were significantly better than those in the control group, there were significant differences between two groups（P 〈 0.05 ）. Conclusion： Yinxingdamo injection in the treatment of PCI for limited stage small cell lung cancer with la- eunorinfacts is safe and effective.

关 键 词：局限期小细胞肺癌 预防性脑照射 腔梗 银杏达莫注射液 

分 类 号：R734.2[医药卫生—肿瘤]