白介素-10基因多态性与湖北汉族人群非霍奇金淋巴瘤患者发病的相关性  

The relationship between IL-10 gene polymorphisms and non-Hodgkin' s lymphoma in Hubei province in Han nationality

作　　者：熊婷[1] 肖琦[2] 陈小琼[1] 肖晖[1] 

机构地区：[1]武汉大学中南医院血液内科,湖北武汉430071 [2]湖北医药学院堰桥医院内科,湖北十堰442000

出　　处：《现代肿瘤医学》2013年第12期2811-2814,共4页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81001053);武汉大学自主项目(编号:4101041)

摘　　要：目的:研究我国湖北汉族人群IL-10基因多态性与非霍奇金淋巴瘤(NHL)发病的关系。方法:采用病例对照研究和聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测363例NHL患者和624例健康对照者中IL-10-592、IL-10-819和IL-10-1082基因型的分布。结果:NHL组与健康对照组相比两组的等位基因及IL-10-592、IL-10-819基因亚型的分布无显著差异(P均>0.05),但NHL患者IL-10-1082 GA基因型频率却显著高于对照组(15%比5%,P=0.000,OR=3.416,95%CI:2.154-5.418);而IL-10-592,IL-10-819和IL-10-1082的基因多态性与NHL患者的病理类型、临床分期及疾病进展之间没有关联(P均>0.05)。结论:IL-10-1082位点基因型与湖北汉族人群NHL发病有相关性。Objective：To study the distribution of IL - 10 gene polymorphisms in patients with non - Hodgkin＇s lymphoma（NHL） inpopalation of Han nationality in Hubei province. Methods：Total of 363 patients with NHL and 624 healthy controls were genotyped by the PCR - RFLP method for IL - 10 -592, IL - 10 -819 and IL - 10 - 1082 polymorphisms. Results：There wasnl significant difference in alleles and genotypes of IL- 10 -592, IL- 10- 819 distribution between the two groups（P 〉 0.05）. But we found that the frequency of IL - 10 - 1082 GA genotype of NHL patients was significantly higher than that in control group（ 15% vs 5% ,P = 0. 000, OR = 3. 416,95% CI：2. 154 - 5.418 ）. There were no associations between IL - 10 - 592, IL - 10 - 819 and IL - 10 - 1082 gene polymorphisms and pathotype ,clinical stages ,and disease progression in NHL patients. Conclusion ：IL- 10 -1082 genotype was as- sociated with NHL in Hubei province in the population of Han nationality.

关 键 词：非霍奇金淋巴瘤 白介素-10 基因多态性 

分 类 号：R733.1[医药卫生—肿瘤]