中国湖南2324例乳腺癌临床特征及分子亚型分析  

Analysis of clinical features and molecular subtype distribution of 2324 breast cancer patients in Hunan province

作　　者：陈飞宇[1] 唐利立[1] 肖志[1] 

机构地区：[1]中南大学湘雅医院乳腺科,湖南长沙410008

出　　处：《中国普通外科杂志》2013年第11期1403-1409,共7页China Journal of General Surgery

基　　金：湖南省科学技术厅课题资助项目(2010TP4053;2011SK3226)

摘　　要：目的:分析中国湖南乳腺癌的临床病理特征、分子亚型的分布特点及其与国内其他地区及国外的差异。方法:回顾性分析湘雅医院2002年1月—2012年9月2 324例女性乳腺癌患者临床病理资料,根据雌激素受体(ER),孕激素受体(PR),Ki-67,表皮生长因子受体(Her-2)的状态,将乳腺癌分为4个分子亚型进行分析。结果:湖南乳腺癌患者的平均年龄47.57岁,绝经前患者(64.5%)多于绝经后患者(35.5%),以中期患者为主。分子亚型分布与国内不同地区及国外比较,差异均有统计学意义(均P<0.05),其中luminal A型比例占59.6%,高于国内上海(52.8%)与广东人群(31.1%)及非裔美籍人群(55.5%),但低于波兰人群(73.0%)与美国人群(66.1%),Her-2型所占比例(5.6%)低于其他人群,而三阴型比例(22.0%)高于大多数其他人群。各分子亚型分布在年龄段、分期、绝经状态及新辅助化疗情况的分组间差异均有统计学意义(均P<0.05)。结论:中国湖南乳腺癌平均发病年龄较轻,绝经前患者多,以luminal A型为主;分子亚型分布与年龄段、分期、绝经状态及新辅助化疗情况有关。Objective： To investigate the clinicopathologic profile and distributional features of molecular subtypes of breast cancer in Hunan Province, and their differences from other geographic regions in China and other countries. Methods： q-he clinicopathologic data of 2 324 breast cancer female patients admitted in Xiangya hospital from January 2002 to September 2012 were reviewed, and the features of molecular subtypes divided by the status of estrogen receptor （ER）, progestrone receptor （PR）, Ki-67, and epidermal growth factor receptor （Her-2） were analyzed. Results： Of the breast cancer patients in Hunan, the average age was 47.57 years, the proportion of premenopausal cases （64.5%） was higher than that ofpostmenopausal cases （35.5%）, and the cases with stage II cancer accounted for the major part; the differences in molecular subtype distribution were all statistically different from those of other geographic regions in China and other countries （all P〈0.0$）; the luminal A subtype accounted for 59.6%, which was higher than that of patients in Shanghai （52.8%）, Guangdong （31.1%）, and among African-Americans （55.5%）, but lower than that of Poles （73.0%） and Americans （66.1%）, and the proportion of Her-2 subtype （5.6%） was lower than that in all other populations while the proportion of triple negative （22.0%） was higher than of the majority of other populations; the molecular subtype distribution had statistical difference between or among the groups divided by age, tumor stage, menstrual status and whether or not neoadiuvant chemotherapy was administered （all P〈0.05）. Conclusion： Among women in China Hunan province, the average age of onset of breast cancer is relatively early, and most of the patients are premenopausal women with luminal A as the predominant subtype; the molecular subtype distribution is related to age, tumor stage, menstrual status and neoadiuvant chemotherapy.

关 键 词：乳腺肿瘤 分子亚型 流行病学 

分 类 号：R737.9[医药卫生—肿瘤]