CD24基因多态性与乳腺癌遗传易感性的关系  

Association between CD24 polymorphism and genetic susceptibility to breast cancer: a case-control study

作　　者：周鑫[1] 曹勇[1] 罗杰[1] 曾晓华[1] 

机构地区：[1]重庆市肿瘤研究所乳腺中心,重庆400030

出　　处：《中南大学学报（医学版）》2013年第11期1122-1129,共8页Journal of Central South University ：Medical Science

基　　金：重庆市科委攻关计划(CSTC;2011AC5189)~~

摘　　要：目的：探讨CD24基因多态性与重庆地区汉族女性乳腺癌遗传易感性的关系。方法：采用病例对照研究，利用Sequenom MassArray？iPLEX GOLD系统对170例乳腺癌患者和178例健康者对照的CD24基因rs3838646和rs52812045单核苷酸多态性进行检测。并对检测结果进行t检验、χ2检验和非条件Logistic回归分析。结果：CD24基因rs3838646多态基因型和等位基因型在乳腺癌组和对照组的分布频率差异无统计学意义（χ2=3.54，P=0.17；χ2=2.29，P=0.13）；以绝经状况进行分层分析，发现与携带CA/CA基因型的绝经前个体比较，携带Del等位基因的个体患乳腺癌的风险显著降低（OR=0.51，95%CI 0.26~1.00，P=0.0485）。CD24基因rs52812045多态基因型和等位基因型在乳腺癌组和对照组的分布频率差异无统计学意义（χ2=5.37，P=0.07；χ2=3.05，P=0.08）；与携带C/C基因型的个体比较，携带T/T基因型的个体患乳腺癌发病风险显著降低（OR=0.47，95%CI 0.23~0.95，P=0.04）。结论：CD24基因多态性可能与重庆地区汉族女性乳腺癌的发病风险相关，但尚须进一步扩大样本量进行检测加以证实。Objective：To evaluate the association between CD24 polymorphism and genetic susceptibility to breast cancer in Chongqing women of Han nationality.Methods：In the case-control study, singlenucleotide polymorphism of CD24 （rs3838646 and rs52812045） was genotyped by Sequenom MassArray？iPLEX GOLD System in 170 patients with breast cancer and 178 healthy controls. Data were analyzed via t test, Chi-square test, and logistic regression analysis. Results：hTe distribution of CD24 rs3838646 genotype and allelotype had no signiifcant difference between the patients with breast cancer and healthy controls （χ2=3.54, P=0.17;χ2=2.29, P=0.13）. Stratiifed by menstruation status, premenopausal individuals carrying CD24 rs3838646 Del allele signiifcantly reduced the risk （OR=0.51, 95%CI 0.26-1.00, P=0.0485） of breast cancer compared with the individuals carrying CD24 CA/CA genotype. The distribution of CD24 rs52812045 genotypes and allelotypes had no signiifcant difference between the patients with breast cancer and healthy controls （χ2=5.37, P=0.07;χ2=3.05, P=0.08）. Compared with C/C homozygotes, CD24 rs52812045 T/T homozygotes had a significantly reduced risk （OR=0.47, 95%CI 0.23-0.95;P=0.04） for breast cancer. Conclusion：CD24 polymorphism may be a marker for susceptibility to breast cancer in Han population in southwestern China. CD24 polymorphisms may be associated with a reduced risk of breast cancer in Chinese population. Further studies are needed to conifrm these ifndings.

关 键 词：乳腺癌 CD24 多态性 遗传易感性 

分 类 号：R737.9[医药卫生—肿瘤]