苯白血病患者GST_μ基因缺失情况分析  

A study on the rates of GST_μgene deletion in leukemia patients exposed to benzene

作　　者：王文静[1] 李昌吉[2] 龙云芳[2] 詹承烈[2] 许峻峰[2] 

机构地区：[1]上海市疾病预防控制中心职业与环境医学科,上海200336 [2]华西医科大学附四院,成都610041

出　　处：《职业卫生与病伤》2000年第4期193-195,共3页Occupational Health and Damage

基　　金：卫生部科研基金项目!(96- 2 - 2 0 5);纽约中华医学基金(CMB)项目

摘　　要：目的 :探讨苯白血病患者 GSTμ 基因缺失频度 ,为进一步研究 GSTμ 基因缺失与苯白血病之间的关系寻找线索。方法 :采用聚合酶链反应 (Polymerase Chain Reaction,PCR)技术检测 GSTμ 基因型。结果 :苯白血病组 GSTμ 基因缺失率为 73.5 3% ,明显高于白血病组 (44 .44% )和对照组 (46 .88% ) (P<0 .0 1 )。苯白血病组的相对危险度为 3.1 5 ,说明在同样接触苯的情况下 ,GSTμ 基因缺失者患苯白血病的危险性是 GSTμ 基因携带者的 3.1 5倍。结论 :GSTμ 基因缺失可能是苯白血病的危险性因素之一。Objective To explore the rates of GST μgene deletion in leukemia patients exposed to benzene.Methods Polymerase chain reaction(PCR)method was used to investigate the rates of GST μgene deletion in 34 cases with leukemia exposed to benzene,27 leukemia patients and 96 healthy controls.Results The rate of GST μgene deletion in leukemia patients exposed to bezene was 73.53%,which was significantly higher than of the controls(44.44%),P<0.01.The absence of the GSTM1 genotype conferred an odds ratio(OR)of 3.15,and the 95% confidence interval(CI)was 0.56 to 17.62.It shows,under the same exposure to benzene circumstance,that the risk of suffering from leukemia exposed to benzene in GST μgene deletin increased by 315%.Leukemia exposed to benzene correlates with GST μgene deletion and GST μgene deletion may act as one of leukemia exposed to benzene.Conclusion GST μ gene deletion may be an important host hereditary marker for susceptibility to leukemia exposed to benzene.

关 键 词：谷胱甘肽巯基转移酶 GSTμ基因缺失 苯白血病 

分 类 号：R733.7[医药卫生—肿瘤]