成釉细胞瘤中基质金属蛋白酶MMP-2的表达及意义  

THE EXPRESSION AND SIGNIFICANCE OF MATRIX METALLOPROTEINASE-2 (MMP-2) IN AMELOBLASTOMA

作　　者：陶谦[1] 黄洪章[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院口腔颌面外科,510120

出　　处：《口腔颌面外科杂志》2000年第4期325-326,共2页Journal of Oral and Maxillofacial Surgery

摘　　要：:目的　探讨成釉细胞瘤局部侵袭性生长的生物学机制。方法　免疫组化 S- P法检测基质金属蛋白酶MMP- 2在成釉细胞瘤中的表达和分布。结果　成釉细胞瘤中 MMP- 2阳性染色位于肿瘤外周柱状细胞的胞浆中 ,中心星网状细胞未见表达 ;角化囊肿和含牙囊肿的上皮细胞中均未见 MMP- 2的阳性表达。结论　成釉细胞瘤细胞产生的 MMP- 2 ,导致基底膜成分 型胶原降解 ,破坏基底膜的完整性 ,这可能是成釉细胞瘤局部侵袭的机制之一。Objective To investigate the mechanism of the biological characteristics of amolobastoma.Methods to detect the expression and site of matrix metalloproteinase-2(MMP-2) in ameloblastoma suing S-P immunohistochemistry.Results MMP-2 positive cells are localized in peripheral columnar while no positive cells are seen in odontogenic karatocysts and dentigerous cysts.Conclusion MMP-2 expressed in ameloblastoma can degrade macromolecules of basement membrane such as collagen Ⅳ and play an important role to facilitate tumor cell invasion.

关 键 词：成釉细胞瘤 基质金属蛋白酶 免疫组化 

分 类 号：R739.803[医药卫生—肿瘤]