TNF-α、IFN-γ在肝纤维化中的发病学意义探讨  

The Pathogenesis Significance of Sorum TNF-αand IFN-γin Liver Fibrosis

作　　者：王子强[1] 徐章[1] 李毅[1] 张兵[1] 胡阳黔[1] 黄晓东[1] 张洁琴[1] 

机构地区：[1]东风汽车公司总医院消化内科,十堰442008

出　　处：《医学新知》2000年第4期184-185,188,共3页New Medicine

摘　　要：为探讨人血清肿瘤坏死因子 - α(TNF- α)、干扰素 - γ(IFN- γ)在肝纤维化中的发病学意义 ,采用双抗体夹心 EL ISA法、放免法测定 115例肝病组、2 0例健康成人对照组血清 TNF- α、IFN- γ及层粘蛋白 (L N)、 、 型前胶原 (PC 、PC )水平。结果显示肝病组 TNF-α、IFN -γ明显高于对照组 (P <0 .0 1) ,L N、PC 同步升高 ,PC 在急性肝炎、慢性肝炎 (中重型 )亦明显增高 (P <0 .0 1)。结果表明 TNF-α、IFN -γ等细胞因子对肝纤维化其有调控作用。To study the pathogenesis significance of serum tumor necrosis factor α(TNF α) and interferon γ(IFN γ) in liver fibrosis,the serum levels of TNF α, IFN γ,Laminin(LN), type Ⅰ procollagen (PCⅠ) and type Ⅲ procollagen (PCⅢ) were measured by means of double antibody sandwish ELISA and RIA kit in 115 patients with various liver disease and 20 normal controls.The TNF α and IFN γ concentration in patients with acute hepatitis, chronic hepatitis or liver cirrhosis were elevated compared with the normal controls (P<0.01).In the same time, the serum levels of LN and PCⅢ were elevated too. The PCⅠ concentration were higher in the patients with acute hepatitis or chronic hepatitis (moderate and grave form) compared with the normal controls (P<0.01).The cell factors such as TNF α and IFN γ are important mediators in the fibrosis regulation.

关 键 词：TNF-Α IFN-Γ 肝纤维化 调控 发病学 

分 类 号：R575.2[医药卫生—消化系统]