Galectin-3蛋白在乳腺癌中的表达及其临床意义  

The Expression and Significance of Galectin-3 protein in Breast Cancer

作　　者：袁媛[1] 张耀龙[2] 宋旭东[3] 姚欣[1] 

机构地区：[1]唐山市妇幼保健院,唐山063000 [2]唐山市协和医院,唐山063000 [3]河北联合大学基础医学院,唐山063000

出　　处：《中国肿瘤临床与康复》2013年第11期1197-1199,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨乳腺癌中Galectin-3蛋白的表达情况及其与临床病理特征与分子亚型的关系。方法采用免疫组化法检测标本中Galectin-3的表达水平。结果 Galectin-3蛋白在乳腺癌组织中及淋巴结转移者中表达增高,且随着组织学分级、临床分期的升高而升高。其表达率在基底细胞亚型高于管腔A型,ER阴性组高于ER阳性组。结论 Galectin-3蛋白参与乳腺癌的发生发展,通过检测有助于对乳腺癌预后及分子亚型的判断,为指导临床激素治疗提供参考。Objective To study relationship between the expression of Galectin-3 protein in breast cancers and clinicopathological features as well as molecular subtypes. Methods Immunohistoehemical method was used to test the expression of Galeetin-3. Results The expression of Galectin-3 in breast cancer and patients with alymph node metastasis were high, and it went up with histological differentiation and clinical stage. The expression rate in thd basal-like was higher than that in luminal A type, and that in ER negative group was higher than ER positive group. Conclusions Galectin-3 involve in the development of breast cancer. It＇s test contribute to the judgment of prognosis and molecular subtypes and provide reference to clinical hormone treatment.

关 键 词：GALECTIN-3 乳腺肿瘤 免疫组化 荧光原位杂交 分子亚型 

分 类 号：R737.9[医药卫生—肿瘤]