脑梗死后血清血小板衍生内皮细胞生长因子浓度变化与神经功能缺损的关系  

Serum concentrations of platelet derived-endothelial cell growth factor in patients with cerebral infarction

作　　者：官俏兵 张晓玲 王琰萍 余波 杜瑛媛[2] 万里红 

机构地区：[1]嘉兴市第二医院神经内科,314000 [2]嘉兴市第二医院生化室,314000

出　　处：《浙江医学》2013年第22期1989-1991,共3页Zhejiang Medical Journal

基　　金：嘉兴市科技局科技计划项目(2010AY1038)

摘　　要：目的研究急性脑梗死后血清血小板衍生内皮细胞生长因子浓度(PD-ECGF)变化与神经功能缺损的关系。方法测定60例脑梗死患者发病后24h内、第3天、第7天、第14天的PD-ECGF浓度,同步评估美国国立卫生研究院脑卒中量表(NIHSS)评分,并记录脑梗死的体积。结果脑梗死患者发病后24h内、第3天、第7天、第14天的平均血清PD-ECGF浓度分别为(4 080.62±1 569.27)、(4 386.03±1 746.05)、(5 473.24±2 312.75)、(3 365.72±1 421.76)pg/ml,4个时点间的差异有统计学意义(F=14.297,P<0.05),并均高于对照组(2 687.92±950.60)pg/ml。相应时点的NIHSS评分分别为(6.35±4.09)、(6.25±4.45)、(5.42±4.44)、(4.68±4.49)分,4个时点间的差异无统计学意义(F=1.925,P>0.05)。发病后第3天脑梗死体积与血清PD-ECGF浓度无相关性(r=0.107,P>0.05),但与NIHSS评分具有相关性(r=0.619,P<0.05)。结论血清PD-ECGF浓度在脑梗死后即有升高,但浓度的高低与神经功能缺损程度和康复无关,与急性脑梗死的病理生理过程相一致。Objective To investigate serum concentrations of platelet derived- endothelial cellgrowth factor （PD- ECGF） in patients with acute cerebral infarction. Methods Sixty patients with acute cerebral infarction were included. Serum concentra-tions of PD- ECGF and scores of National Institutes of Health Stroke Scale （NIHSS） were measured at 24h and d3, 7, 14 after the onset of stroke;and the volume of infarction were also documented. Results The mean values of serum PD- ECGF concentrations at 24 hours and d3, 7, 14 after onset were 4 080.62±1 569.27pg/ml, 4 386.03±1 746.05pg/ml, 5 473.24±2 312.75pg/ml and 3 365.72±1 421.76pg/ml, respectively（F=14.297, P〈0.05）, which were al higher than that of controls（2 687.92±950.60pg/ml, P〈0.05）. NIHSS scores at the corresponding time points were 6.35 ±4.09, 6.25 ±4.45, 5.42 ±4.44 and 4.68 ±4.49, respectively （F=1.925, P〉0.05）. The serum PD- ECGF concentrations were not correlated with cerebral infarction volumes（r=0.107, P〉0.05）, but the cerebral infarction volume on d3 after the onset was correlated with NIHSS score （r=0.619, P〈0.05）. Conclusion The serum concentrations of PD- ECGF begin to rise after occurrence of infarction, which are consistent with the pathophysiological process of acute cerebral infarction, but not correlated with the degree of neurological impairment or rehabilitation.

关 键 词：血小板衍生内皮细胞生长因子 脑梗死 神经功能缺损 

分 类 号：R743.3[医药卫生—神经病学与精神病学]