肝脏血流灌注参数计算的研究  

A Study on Hepatic Perfusion Parameter Calculation

作　　者：彭凡[1] 沈比先[2] 廖振华[3] 刘伟强[1,3] 

机构地区：[1]清华大学医学院生物医学工程系,北京100084 [2]深圳市南山区人民医院,深圳518052 [3]深圳清华大学研究院,深圳518057

出　　处：《生物医学工程学杂志》2013年第6期1250-1253,共4页Journal of Biomedical Engineering

摘　　要：肝脏血流灌注参数是临床上检测和诊断肝脏弥漫性疾病的重要参考指标。本文提出了一种基于血流动力学模型对血流灌注参数进行快速、准确的计算方法。该方法通过引入肝脏血流双端输入一端输出的一房室模型,建立肝脏各部分血流之间的联系。采用Gaussian函数对灌注过程中门静脉和肝动脉的对比剂浓度—时间数据进行拟合,进一步得到肝实质中对比剂浓度随时间变化精确的数学表达式。最后使用Levenberg—Marquardt算法求解模型参数,计算得出血流灌注参数。对灌注数据的计算分析结果表明,该方法能够准确计算出反映肝脏血流动力学性能的各种参数,具有广泛的应用价值。Hepatic perfusion parameters play an important role in detecting and diagnosing diffusion diseases of liver. Based on a hemodynamic model. In this study, we described a fast and accurate method to calculate the perfusion pa- rameters. First, we used a dual-input one-compartment kinetics model to illustrate the distribution of the contrast a- gent concentration among the body. Then, we used the Gaussian function to fit the scatter concentration data of por- tal vein and aorta, to obtain a liver agent concentration on function of time. Finally, we solved the model parameters by using Levenberg--Marquardt algorithm, and calculated the perfusion parameters. The results showed that the method proposed in this study could calculate the parameters precisely, and had a prosperous future application possibility.

关 键 词：肝脏灌注 血流动力学 曲线拟合 高斯函数 

分 类 号：R575[医药卫生—消化系统]