DNA甲基化模式及其在癌症中的作用  

DNA Methylation Patterns and Their Roles in Cancers

作　　者：虞游[1] 朱涵[1] 卢佳伟[1] 姚卉卉 陈建明[1] 

机构地区：[1]杭州师范大学生命与环境科学学院,杭州310036

出　　处：《中国细胞生物学学报》2013年第12期1813-1819,共7页Chinese Journal of Cell Biology

基　　金：浙江省钱江人才计划(批准号:2010R10062);浙江省新苗人才计划(批准号:2013R421053);<细胞生物学>市级精品课程(批准号:ZX13007002001)资助的课题~~

摘　　要：随着对癌症研究的不断深入,表观遗传调控在癌症发生发展中的作用也越来越受到人们的关注。DNA甲基化作为一种重要的表观遗传修饰机制,在基因表达调控中起着十分重要的作用。该文对DNA甲基化模式及其在癌症中的作用作了综述,并对DNA甲基化作为癌症早期诊断的生物标记以及癌症表观治疗的新策略作了总结和展望。With the deepening of the research on cancers, epigenetic regulation is now gaining more and more concern about its effects on the occurrence and development of cancers. DNA methylation, an important mechanism in epigenetic modifications, plays a significant role in the regulation of gene expression. In this review, DNA methylation patterns and their roles in cancers were reviewed. Additionally, DNA methylation as the bio- marker in the early diagnosis of cancers and the new strategy in the epigenetic therapy of cancers were summarized and their futures were prospected.

关 键 词：DNA甲基化 癌症 表观遗传 生物标记 表观治疗 

分 类 号：R730.2[医药卫生—肿瘤]