化疗对肺癌患者生活质量的影响  

Effect of Chemotherapy on the Quality of Life of Lung Cancer Patients

作　　者：刘旭[1,2,3] 王燕[2] 李淑芳[2] 辛士珍[4] 曹建存[4] 

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津医科大学总医院肿瘤科,天津300052 [3]天津市西青医院呼吸科,天津300380 [4]天津海河医院呼吸科,天津300350

出　　处：《中国肺癌杂志》2013年第12期656-660,共5页Chinese Journal of Lung Cancer

摘　　要：背景与目的随着现代医学的发展,不仅要求医护人员要消除患者病痛和心理障碍,还要提高患者生活质量。本研究探讨化疗对肺癌患者生活质量的影响及其影响因素。方法随机抽取住院化疗的肺癌患者61例,分别于化疗前、化疗2周期后1周内、化疗4周期后1周内评估临床疗效,并进行肺癌患者生活质量量表(EORTC QLQ-30)问卷调查。结果化疗2周期后化疗有效率40%,患者社会功能下降,恶心、呕吐、失眠、厌食症状加重(P<0.05)。化疗4周期后化疗有效率23%,患者化疗后躯体、角色、情绪、社会功能降低,恶心呕吐、食欲减退、失眠症状加重,经济困难较化疗前加重(P<0.05)。生活质量影响因素分析:女性较男性易疲倦、食欲减退(P<0.05)。文化程度低者较文化程度高者易失眠、疲倦(P<0.05)。老年患者较中年人更易出现疲倦、食欲减退、恶心呕吐(P<0.05)。按体重指数分为消瘦、正常、超重三组,三组比较生活质量无明显统计学差异(P>0.05)。按血浆白蛋白水平分为低白蛋白组及正常白蛋白组,两组比较生活质量无明显统计学差异(P>0.05)。但前组症状及经济困难得分较高,后组功能领域及总体健康状况得分较高。结论化疗可使肺癌患者肿瘤减小,临床症状缓解,但化疗后患者易疲劳、纳差、恶心呕吐加重,患者情绪较差,生活质量降低,应注重患者化疗不良反应并及时予处理,加强对患者的心理疏导,增加患者的营养,提高患者的生活质量。Background and objective With development of modern medicine, eliminating patients＇ pain and mental disorder and improving the quality of life has become an important problem in patients with cancer. The aim of this study is to observe the impact of chemotherapy on quality of life and influencing factor of quality of life among lung cancer patients. Methods Sixty-one lung cancer patients were assessed with clinical outcomes and the EORTC Q.LQ.-C30 question- naires before chemotherapy, one week after 2 cycles of chemotherapy, one week after 4 cycles of chemotherapy. Results After 2 cycles of chemotherapy, effective rate was 40.0%. Social function decreased. Nanse and vomiting, insomnia and appetite loss deteriorated （P〈0.05）. After 4 cydes of chemotherapy, effective rate was 23%. But after chemotherapy, physical, role, emo- tional, social function decreased; Appetite loss, nausea and vomiting, insomnia deteriorated, economics became difficult to some patients （P〈0.05）. In our study, we find female patients had more fatigue and appetite loss than male patients （P〈0.05）. Patients of low level of education had more fatigue and insomnia than patients of high level of education （P〈0.05）. Elder pa- tients had more fatigue, appetite loss, nausea and vomiting than middle-aged patients （P〈0.0S）. Grouped according to body mass index, the difference wasn＇t statistically significant （P〉0.05）. Grouped according to the plasma albumin level, the differ- ence wasn＇t statistically significant （P〉0.05）. In hypoproteinemia group, symptoms and economic difficulties score was higher; High protein group, function and general health scores was higher. Conclusion After the chemotherapy, patients＇ the lesion of cancer became smaller and clinical symptoms relieved, but some patients, fatigue, appetite loss, nausea and vomiting symptom deteriorated, emotion became bad. Quality of life of lung cancer patients decrease. We should pay more attention to the adverse reactions of chemotherapy and

关 键 词：肺肿瘤 化疗 生活质量 

分 类 号：R734.2[医药卫生—肿瘤]