αB-crystallin在基底细胞样型乳腺癌中的表达及临床意义  

Clinical significance and expression of αB-crystallin in basal-like breast cancer

作　　者：石艳宏[1] 郑洪彦[1] 张丽芳[1] 陈英准[1] 

机构地区：[1]哈尔滨医科大学附属第二医院病理科,哈尔滨150086

出　　处：《临床肿瘤学杂志》2013年第11期974-977,共4页Chinese Clinical Oncology

基　　金：黑龙江省教育厅科学技术研究资助项目(11531131)

摘　　要：目的观察小热休克蛋白α-basic-crystallin(αB-crystallin)在基底细胞样型乳腺癌(BLBC)中的表达,分析其与BLBC临床病理特征的关系。方法采用免疫组织化学SP法检测αB-crystallin在108例BLBC和342例非基底细胞样型乳腺癌(NBLBC)中的表达。结果αB-crystallin在BLBC中的阳性表达率为56.5%,高于其在NBLBC中的7.9%(P<0.05)。αB-crystallin在BLBC中的表达与组织学分级有相关性(r=0.313,P<0.001),与年龄、肿瘤大小及淋巴结转移均无相关性(P>0.05)。结论αB-crystallin可能是BLBC发生、发展的重要参与者,可作为BLBC预后不良的指标。Objective To investigate the expression of α-basic-crystallin （αtB-crystallin） in basal-like breast cancer（BLBC）,and analyze the association between its expression and the clinicopathological characteristics in BLBC.Methods The SP immunohistochemical technique was used to examine the expression of oαB-crystallin in 108 cases of BLBC and 342 cases of non-basal-like breast cancer（NBLBC）.Results By statistical analysis,it showed that the positive rate of αB-crystallin was 56.5% in BLBC,significantly higher than 7.9% in NBLBC（P 〈0.05）.The expression of αB-crystallin was found to be positively correlated with histological grading of tumor （r =0.313,P 〈 0.001）,but not with age,tumor size and lymph node metastasis （P 〉 0.05）.Conclusion αB-crystallin may play an important role in the progression of BLBC.Furthermore,it also may be a marker which can predict poor clinical outcome in BLBC.

关 键 词：基底细胞样乳腺癌 免疫组织化学 αB-crystallin 

分 类 号：R737.9[医药卫生—肿瘤]