CD147和MMP-9在结直肠癌组织中的表达及临床意义  

Expressions and significances of CD147 and MMP-9 in colorectal cancer

作　　者：陈娟[1] 卢宁[1] 黄建国[1] 王勇强[1] 赵晓伟[1] 谢伟[1] 

机构地区：[1]兰州军区乌鲁木齐总医院肿瘤诊疗中心,乌鲁木齐830000

出　　处：《临床肿瘤学杂志》2013年第11期982-985,共4页Chinese Clinical Oncology

基　　金：兰州军区医药卫生科研计划课题资助项目(LXH2008032)

摘　　要：目的探讨CD147和基质金属蛋白酶(MMP)-9在结直肠癌中的表达及临床意义。方法采用免疫组化法检测60例结直肠癌和50例癌旁组织中CD147和MMP-9的表达,并分析两者表达与结直肠癌临床病理特征的关系。结果结直肠癌组织中CD147及MMP-9的阳性表达率分别为86.7%和85.0%,高于癌旁组织中的20.0%和15.0%(P<0.05)。两者表达与年龄、性别、肿瘤部位、分化程度、pTNM分期、淋巴结转移、浸润深度和远处转移均无关。CD147和MMP-9在结直肠中的表达呈正相关(r=0.470,P<0.001)。结论 MMP-9及其诱导因子CD147在结直肠癌组织中高表达,两者与结直肠癌发生、发展的关系需进一步研究。Objective To investigate the expressions of CD147 and MMP-9 in colorectal cancer,and the correlation of them with cliniopathological characteristics.Methods Expressions of CD147 and MMP-9 in 60 colorectal cancer and 50 adjacent normal tissues were detected by immunohistochemistry,and the relationship of their expressions with clinical characteristics was further analyzed.Results The positive rates of the expressions of CD147 and MMP-9 in 60 cases of colorectal cancer tissues were 86.7% and 85.0%,higher than 20.0% and 15.0% in adjacent normal tissues（P 〈0.05）.CD147 and MMP-9 were not related to age,gender,tumor location,differentiation,TNM stage,lymph node metastasis and distant metastasis.CD147 was positively correlated with MMP9（r =0.470,P 〈0.001）.Conclusion MMP-9 and CD147 were over-expressed in colorectal cancer.The role of them in colorectal cancer needs further study.

关 键 词：CD147 基质金属蛋白酶9 结直肠癌 

分 类 号：R735.3[医药卫生—肿瘤]