^(18)F-FDGPET/CT诊断非小细胞肺癌纵隔淋巴结转移  

^(18)F-FDG PET/CT in diagnosing mediastinal lymph node metastasis from non-small cell lung cancer

作　　者：许泽清[1] 段小蓓[2] 贾晓娟[1] 樊卫[3] 

机构地区：[1]中山大学附属第五医院核医学科,广东珠海519000 [2]江门市中心医院核医学科,广东江门529030 [3]中山大学肿瘤防治中心核医学科,广东广州510060

出　　处：《中国医学影像技术》2013年第12期1989-1993,共5页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨18F-FDG PET/CT诊断非小细胞肺癌(NSCLC)纵隔淋巴结转移的价值。方法回顾性分析130例初诊NSCLC患者(337个纵隔淋巴结)术前PET/CT资料,与术后病理结果相对照,评价PET/CT诊断NSCLC纵隔淋巴结转移的灵敏度、特异度及准确率。结果以患者为观察单位,PET/CT发现纵隔淋巴结转移66例,无纵隔淋巴结转移64例,灵敏度79.41%(54/68),特异度80.65%(50/62),准确率80.00%(104/130),阳性预测值81.82%(54/66),阴性预测值78.13%(50/64);以淋巴结数为单位,PET/CT诊断纵隔淋巴结转移125个,非纵隔淋巴结212个,PET/CT诊断纵隔淋巴结转移的灵敏度74.42%(96/129),特异度86.06%(179/208),准确率81.60%(275/337),阳性预测值76.80%(96/125),阴性预测值84.43%(179/212)。PET/CT结果与病理结果比较差异无统计学意义。结论 18 F-FDG PET/CT诊断NSCLC纵隔淋巴结转移具有较高价值。Objective To explore the value of 18F-FDG PET/CT in diagnosing mediastinal lymph node metastasis from non-small cell lung cancer （NSCLC）. Methods A total of 130 histologically proved NSCLC patients with 337 nodal stations without any therapy who underwent 18F-FDG PET/CT were reviewed. Pathologic nodal classifications were used as the final standards to evaluate the sensitivity, specificity and accuracy rate of PET/CT. Results Taking patients as research object, PET/CT showed mediastinal lymph node metastasis in 66 patients, and the sensitivity, specificity, accuracy rate, positive predictive value and negative predictive value were 79.41% （54/68）, 80.65% （50/62）, 80.00% （104/130）, 81.82% （54/66） and 78.13% （50/64）, respectively. Taking lymph node as research object, 125 lymph nodes were diagnosed positive, and the sensitivity, specificity, accuracy rate, positive predictive value and negative predictive value were 74.42% （96/129）, 86.06% （179/208）, 81.60% （275/337）, 76.80% （96/125） and 84.43% （179/212）, respectively. There was no statistical difference between results of PET/CT and pathology. Conclusion 18F-FDG PET/CT has high diagnostic value for mediastinal lymph node metastasis from NSCLC.

关 键 词：癌 非小细胞肺 正电子发射型体层摄影术 18F氟脱氧葡萄糖 肿瘤分期 

分 类 号：R734.2[医药卫生—肿瘤] R817.4[医药卫生—临床医学]