Synthesis of Nitroanilines Catalyzed by Horseradish Peroxidase in the Presence of NaNO2 and H2O2  

作　　者：LIU Cong DAI Rong-ji LIN Jie SUN Jian-hua CHEN Shi DENG Yu-lin 

机构地区：[1]School of Life Science, Beijing Institute of Technology, Beijing 100081, P.R.China

出　　处：《Chemical Research in Chinese Universities》2013年第6期1164-1166,共3页高等学校化学研究（英文版）

摘　　要：The synthesis of nitroanilines catalyzed by horseradish peroxidase（HRP） in the presence of sodium nitrite and hydrogen peroxide was investigated, o-Nitroaniline and p-nitroaniline were found in the nitrated products. 2-Aminotoluene and 4-aminotoluene could also be nitrated to give corresponding nitrated products. This protocol has great potentials to open new avenues useful for the synthesis of nitroaniline and its derivatives.The synthesis of nitroanilines catalyzed by horseradish peroxidase（HRP） in the presence of sodium nitrite and hydrogen peroxide was investigated, o-Nitroaniline and p-nitroaniline were found in the nitrated products. 2-Aminotoluene and 4-aminotoluene could also be nitrated to give corresponding nitrated products. This protocol has great potentials to open new avenues useful for the synthesis of nitroaniline and its derivatives.

关 键 词：NITROANILINE Horseradish peroxidase Phenylamine NITRATION ENZYME 

分 类 号：TQ246.38[化学工程—有机化工] Q554.6[生物学—生物化学]