TAMs在贲门癌和非贲门癌组织中的表达及其临床意义  

TAMs Expression in the Different Locations of Gastric Cancer and its Clinicopathologic Significance

作　　者：韩伟[1] 王正彩[2] 周敏[1] 顾云鹤[1] 胡成乙[2] 张淑君[2] 吴红梅[1] 齐蕾[3] 周秋锋[1] 王瑞芬[4] 管雯斌[4] 王立峰[4] 

机构地区：[1]哈尔滨医科大学附属第一医院病理科,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属第四医院病理科,黑龙江哈尔滨150001 [3]邢台市人民医院,河北邢台054031 [4]上海交通大学医学院附属新华医院病理科,上海200092

出　　处：《现代生物医学进展》2013年第31期6073-6076,共4页Progress in Modern Biomedicine

基　　金：黑龙江省教育厅科学技术研究项目(12511191)

摘　　要：目的:观察不同部位胃癌(贲门癌与非贲门癌)组织中肿瘤相关巨噬细胞(tumor associated macrohags,TAMs)的表达及其与血管生成的关系,并进一步分析其与临床病理特征的相关性。方法:利用免疫组化方法标记TAMs(抗CD68抗体)和血管内皮细胞(抗CD34抗体),检测90例胃癌中(包括18例贲门癌与72例非贲门癌)TAMs、微血管密度(microvessel density,MVD)的表达情况。结果:①TAMs与胃癌的部位、分化程度、浸润深度及临床分期呈显著正相关(P均<0.05);②MVD与胃癌的部位和分化程度呈显著正相关(P<0.05);结论:TAM可以促进胃癌的发展,这可能与TAM促进肿瘤的血管生成有关;TAM的表达可能是影响贲门癌与非贲门癌生物学行为差异的因素之一。Objective： To investigate the expression of tumor associated macrophages （TAMs） and the relationship with tumor angiogenesis and clinical pathological characteritics in different locations of gastric cance r （Cardia Carcinoma and Non-cardia Carcinoma）. Methods： The expression of TAMs, microvessel density （MVD） in 90 cases of gastric cancer samples （including 18 cardia carcinoma and 72 non-cardia carcinoma） were stained using double-immunostaining method allowing simultaneous identification of macrophages and endothelial cells. Results： ① TAMs density had a positive relationship with the location, cancer differentiation, the depth of infiltration, and clinical stages （P 〈0.05）; ② MVD had a positive correlation with location, and cancer differentiation, （P 〈 0.05）. Conclusions： TAMs could assist tumor cell intravasation through promoting angiogenesis in gastric cancer, and the expression of TAMs may be one of the reasons affecting different biological behaviors of cardia and non-cardia cancer.

关 键 词：胃癌 肿瘤相关巨噬细胞 贲门癌 血管生成 

分 类 号：R735.2[医药卫生—肿瘤]