Hedgehog信号通路靶基因与肿瘤的关系之研究进展  

Research Progress of the Hedgehog Signaling Pathway Target Genes and Tumor

作　　者：程萍[1] 郭传勇[1] 徐选福[1] 

机构地区：[1]同济大学附属第十人民医院消化科,上海200072

出　　处：《现代生物医学进展》2013年第32期6393-6395,6398,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81270515;81072005;81172312);上海市科委创新行动计划国际合作课题(11430702400)

摘　　要：Hedgehog(HH)蛋白属于分泌蛋白家族,广泛表达于哺乳动物,非哺乳动物等多个物种,参与调控多种肿瘤形成,器官成熟、血管生成,干细胞分化,免疫细胞以及胚胎发育。文章主要就近几年来国内外对hedgehog信号通道下游靶基因在肿瘤干细胞,肿瘤细胞的转移,增殖,凋亡及胚胎发育等方面的研究进展进行综述,重点阐述hedgehog信号通路下游靶基因与肿瘤及发育的关系,以期能为与hedgehog信号通道参与调控的相关疾病提供一些靶向性临床诊疗的新思路。Hedgehog （HH） protein belongs to a family of secreted proteins, which is widely expressed in mammals and non- mammals species and is involved in the regulation of a variety of tumor formation in mature organs, angiogenesis, stem cell differentiation, immune cells, and embryonic development. This articles is mainly about the research progress of the hedgehog signaling pathway down- stream target genes in cancer stem cells, tumor cell metastasis, proliferation, apoptosis and embryonic development in recent years on home and abroad. Here I review the connections between the hedgehog signaling pathway downstream target genes and tumor develop- ment. This may give us a new clinical idea of treat realated disease.

关 键 词：HEDGEHOG信号通路 信号转导 肿瘤 胚胎发育 靶基因 

分 类 号：R730.231[医药卫生—肿瘤]